Critical applications of Mucor circinelloides within a biorefinery context

Cristiano E. Rodrigues Reis, Heitor B.S. Bento, Ana K.F. Carvalho, Aravindan Rajendran, Bo Hu, Heizir F. De Castro

Research output: Contribution to journalReview article

8 Scopus citations


The establishment of an efficient and feasible biorefinery model depends on, among other factors, particularly the selection of the most appropriate microorganism. Mucor circinelloides is a dimorphic fungus species able to produce a wide variety of hydrolytic enzymes, lipids prone to biodiesel production, carotenoids, ethanol, and biomass with significant nutritional value. M. circinelloides also has been selected as a model species for genetic modification by being the first filamentous oleaginous species to have its genome fully characterized, as well as being a species characterized as a potential bioremediation agent. Considering the potential of replacing several nonrenewable feedstocks is widely dependent on fossil fuels, the exploitation of microbial processes and products is a desirable solution for promoting a green and sustainable future. Here, we introduce and thoroughly describe the recent and critical applications of this remarkable fungus within the context of developing a fungal-based biorefinery.

Original languageEnglish (US)
Pages (from-to)555-570
Number of pages16
JournalCritical Reviews in Biotechnology
Issue number4
StatePublished - May 19 2019


  • Mucor circinelloides
  • biorefinery
  • bioremediation
  • carotenoids
  • enzymes
  • filamentous fungi
  • lipids
  • zygomycete

PubMed: MeSH publication types

  • Journal Article
  • Review

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    Rodrigues Reis, C. E., Bento, H. B. S., Carvalho, A. K. F., Rajendran, A., Hu, B., & De Castro, H. F. (2019). Critical applications of Mucor circinelloides within a biorefinery context. Critical Reviews in Biotechnology, 39(4), 555-570.