CRH challenge test in anxious depression

William H. Meller; Roger G. Kathol; Stephen D. Samuelson; Timothy L. Gehris; Brendon T. Carroll; Andrew F. Pitts; Paula J. Clayton

doi:10.1016/0006-3223(94)00132-M

CRH challenge test in anxious depression

William H. Meller, Roger G. Kathol, Stephen D. Samuelson, Timothy L. Gehris, Brendon T. Carroll, Andrew F. Pitts, Paula J. Clayton

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Recently, renewed interest has developed in the concept of anxious depression. Using an operational definition of "anxious depression" based on the SADS interview, 25 patients with major depressive disorder were separated into anxious (n = 14) and nonanxious (n = 11) subtypes. These two patient groups and normal control subjects received an intravenous corticotropin-releasing hormone challenge test. Adrenocorticotropic hormone (ACTH) and cortisol responses were compared among the three groups. Patients with anxious depression had significant attenuation of ACTH response when compared to nonanxious patients and normal control subjects.

Original language	English (US)
Pages (from-to)	376-382
Number of pages	7
Journal	Biological psychiatry
Volume	37
Issue number	6
DOIs	https://doi.org/10.1016/0006-3223(94)00132-M
State	Published - Mar 15 1995

Keywords

Corticotropin-releasing hormone
anxious depression

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10.1016/0006-3223(94)00132-M

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abstract = "Recently, renewed interest has developed in the concept of anxious depression. Using an operational definition of {"}anxious depression{"} based on the SADS interview, 25 patients with major depressive disorder were separated into anxious (n = 14) and nonanxious (n = 11) subtypes. These two patient groups and normal control subjects received an intravenous corticotropin-releasing hormone challenge test. Adrenocorticotropic hormone (ACTH) and cortisol responses were compared among the three groups. Patients with anxious depression had significant attenuation of ACTH response when compared to nonanxious patients and normal control subjects.",

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AU - Meller, William H.

AU - Kathol, Roger G.

AU - Samuelson, Stephen D.

AU - Gehris, Timothy L.

AU - Carroll, Brendon T.

AU - Pitts, Andrew F.

AU - Clayton, Paula J.

PY - 1995/3/15

Y1 - 1995/3/15

N2 - Recently, renewed interest has developed in the concept of anxious depression. Using an operational definition of "anxious depression" based on the SADS interview, 25 patients with major depressive disorder were separated into anxious (n = 14) and nonanxious (n = 11) subtypes. These two patient groups and normal control subjects received an intravenous corticotropin-releasing hormone challenge test. Adrenocorticotropic hormone (ACTH) and cortisol responses were compared among the three groups. Patients with anxious depression had significant attenuation of ACTH response when compared to nonanxious patients and normal control subjects.

AB - Recently, renewed interest has developed in the concept of anxious depression. Using an operational definition of "anxious depression" based on the SADS interview, 25 patients with major depressive disorder were separated into anxious (n = 14) and nonanxious (n = 11) subtypes. These two patient groups and normal control subjects received an intravenous corticotropin-releasing hormone challenge test. Adrenocorticotropic hormone (ACTH) and cortisol responses were compared among the three groups. Patients with anxious depression had significant attenuation of ACTH response when compared to nonanxious patients and normal control subjects.

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CRH challenge test in anxious depression

Abstract

Keywords

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