Exogenous corticotropin releasing factor (CRF) causes centrally mediated behavioral changes including decreased feeding and increased grooming. These behavioral changes are also seen in response to some stressors. However, the role of endogenous CRF in the behavioral response to stressors has not been investigated fully. We report below our findings on the behavioral effects of alpha-helical CRF (9-41), a recently discovered competitive antagonist of CRF-induced ACTH release. Alpha-helical CRF (9-41) partially reversed the decrement in feeding induced by CRF. Furthermore, the reduction in food intake due to restraint stress was partially reversed by alpha-helical CRF (9-41). These results indicate that changes in endogenous CRF release induced by the restraint Stressor may play a role in stress-induced anorexia.
|Original language||English (US)|
|Number of pages||5|
|Journal||Brain Research Bulletin|
|State||Published - Sep 1986|
Bibliographical noteFunding Information:
This work was supported by the VeteransA dministrationM edi-cal Center Researchf unds. We would like to thank JoAnn Tallman for secretarial assistance.
- CRF (9-41)