Study question: What barriers related to limitations of space or facilities do nurse practitioners (NPs) describe in association with their current practice? Method: This was a descriptive quantitative/qualitative study of 81 NPs in one Midwestern state with a survey instrument previously developed under the auspices of the Division of Nursing and the American Association of Colleges of Nursing regarding advanced practice nursing. Results: Of 641 questionnaires mailed to the total number of prescribing NPs in the state, 372 (58%) were returned. Of that number, 81 (22%) indicated that space limitations were a barrier to practice. Seven themes emerged in qualitative analysis of their narrative descriptions of this barrier. Discussion: Results of this study can assist NPs to articulate their space requirements and enhance existing spaces to better meet patient and NP needs.