Creating APP transgenic lines in mice

Stanley Jones Premkumar Iyadurai, Karen H Ashe

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disease that primarily impairs memory function. 1 Pathologically, AD is characterized by amyloid-containing neuritic plaques and intraneuronal fibrillary tangles. 2 While the biological causes and exact biological mechanisms by which the progressive neurodegeneration is initiated are not very clear, it has been shown that mutations in some specific genes may be important in these events. For example, mutations in genes encoding the amyloid precursor protein (APP), 3-9 presenilin-1 (PS1) and presenilin-2 (PS2) 10-13 have been associated with cases of familial AD.

Original languageEnglish (US)
Title of host publicationAmyloid Precursor Protein
Subtitle of host publicationA Practical Approach
PublisherCRC Press
Pages185-200
Number of pages16
ISBN (Electronic)9780203492185
ISBN (Print)9780849322457
StatePublished - Jan 1 2004

Fingerprint

Amyloid beta-Protein Precursor
Alzheimer Disease
Presenilin-2
Presenilin-1
Mutation
Amyloid Plaques
Amyloid
Neurodegenerative Diseases
Neurodegenerative diseases
Genes
Gene encoding
Data storage equipment
Alzheimer disease type 1

Cite this

Iyadurai, S. J. P., & Ashe, K. H. (2004). Creating APP transgenic lines in mice. In Amyloid Precursor Protein: A Practical Approach (pp. 185-200). CRC Press.

Creating APP transgenic lines in mice. / Iyadurai, Stanley Jones Premkumar; Ashe, Karen H.

Amyloid Precursor Protein: A Practical Approach. CRC Press, 2004. p. 185-200.

Research output: Chapter in Book/Report/Conference proceedingChapter

Iyadurai, SJP & Ashe, KH 2004, Creating APP transgenic lines in mice. in Amyloid Precursor Protein: A Practical Approach. CRC Press, pp. 185-200.
Iyadurai SJP, Ashe KH. Creating APP transgenic lines in mice. In Amyloid Precursor Protein: A Practical Approach. CRC Press. 2004. p. 185-200
Iyadurai, Stanley Jones Premkumar ; Ashe, Karen H. / Creating APP transgenic lines in mice. Amyloid Precursor Protein: A Practical Approach. CRC Press, 2004. pp. 185-200
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