Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer

Olivia A. Maguire; Sarah E. Ackerman; Sarah K. Szwed; Aarthi V. Maganti; François Marchildon; Xiaojing Huang; Daniel J. Kramer; Adriana Rosas-Villegas; Rebecca G. Gelfer; Lauren E. Turner; Victor Ceballos; Asal Hejazi; Bozena Samborska; Janane F. Rahbani; Christien B. Dykstra; Matthew G. Annis; Ji Dung Luo; Thomas S. Carroll; Caroline S. Jiang; Andrew J. Dannenberg; Peter M. Siegel; Sarah A. Tersey; Raghavendra G. Mirmira; Lawrence Kazak; Paul Cohen

doi:10.1016/j.cmet.2021.01.018

Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer

Olivia A. Maguire
, Sarah E. Ackerman
, Sarah K. Szwed
, Aarthi V. Maganti
, François Marchildon
, Xiaojing Huang
, Daniel J. Kramer
, Adriana Rosas-Villegas
, Rebecca G. Gelfer
, Lauren E. Turner
, Victor Ceballos
, Asal Hejazi
, Bozena Samborska
, Janane F. Rahbani
, Christien B. Dykstra
, Matthew G. Annis
, Ji Dung Luo
, Thomas S. Carroll
, Caroline S. Jiang
, Andrew J. Dannenberg

Peter M. Siegel, Sarah A. Tersey, Raghavendra G. Mirmira, Lawrence Kazak, Paul Cohen

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

Obesity is a major risk factor for adverse outcomes in breast cancer. Maguire, Ackerman et al. reveal Gatm and Acsbg1 as molecular regulators of obesity-driven breast cancer progression. They further show that in obesity creatine is a key metabolite in the crosstalk between adipocytes and breast tumors.

Original language	English (US)
Pages (from-to)	499-512.e6
Journal	Cell Metabolism
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/j.cmet.2021.01.018
State	Published - Mar 2 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc.

Keywords

Acsbg1
breast cancer
creatine
Gatm
hypoxia
obesity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1016/j.cmet.2021.01.018

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Maguire, O. A., Ackerman, S. E., Szwed, S. K., Maganti, A. V., Marchildon, F., Huang, X., Kramer, D. J., Rosas-Villegas, A., Gelfer, R. G., Turner, L. E., Ceballos, V., Hejazi, A., Samborska, B., Rahbani, J. F., Dykstra, C. B., Annis, M. G., Luo, J. D., Carroll, T. S., Jiang, C. S., ... Cohen, P. (2021). Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer. Cell Metabolism, 33(3), 499-512.e6. https://doi.org/10.1016/j.cmet.2021.01.018

Maguire, OA, Ackerman, SE, Szwed, SK, Maganti, AV, Marchildon, F, Huang, X, Kramer, DJ, Rosas-Villegas, A, Gelfer, RG, Turner, LE, Ceballos, V, Hejazi, A, Samborska, B, Rahbani, JF, Dykstra, CB, Annis, MG, Luo, JD, Carroll, TS, Jiang, CS, Dannenberg, AJ, Siegel, PM, Tersey, SA, Mirmira, RG, Kazak, L & Cohen, P 2021, 'Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer', Cell Metabolism, vol. 33, no. 3, pp. 499-512.e6. https://doi.org/10.1016/j.cmet.2021.01.018

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title = "Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer",

abstract = "Obesity is a major risk factor for adverse outcomes in breast cancer. Maguire, Ackerman et al. reveal Gatm and Acsbg1 as molecular regulators of obesity-driven breast cancer progression. They further show that in obesity creatine is a key metabolite in the crosstalk between adipocytes and breast tumors.",

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doi = "10.1016/j.cmet.2021.01.018",

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AU - Maguire, Olivia A.

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AU - Marchildon, François

AU - Huang, Xiaojing

AU - Kramer, Daniel J.

AU - Rosas-Villegas, Adriana

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AU - Turner, Lauren E.

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AU - Rahbani, Janane F.

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AU - Annis, Matthew G.

AU - Luo, Ji Dung

AU - Carroll, Thomas S.

AU - Jiang, Caroline S.

AU - Dannenberg, Andrew J.

AU - Siegel, Peter M.

AU - Tersey, Sarah A.

AU - Mirmira, Raghavendra G.

AU - Kazak, Lawrence

AU - Cohen, Paul

PY - 2021/3/2

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AB - Obesity is a major risk factor for adverse outcomes in breast cancer. Maguire, Ackerman et al. reveal Gatm and Acsbg1 as molecular regulators of obesity-driven breast cancer progression. They further show that in obesity creatine is a key metabolite in the crosstalk between adipocytes and breast tumors.

KW - Acsbg1

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KW - creatine

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KW - hypoxia

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ER -

Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer

Abstract

Bibliographical note

Keywords

UN SDGs

Publisher link

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