Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer

Olivia A. Maguire; Sarah E. Ackerman; Sarah K. Szwed; Aarthi V. Maganti; François Marchildon; Xiaojing Huang; Daniel J. Kramer; Adriana Rosas-Villegas; Rebecca G. Gelfer; Lauren E. Turner; Victor Ceballos; Asal Hejazi; Bozena Samborska; Janane F. Rahbani; Christien B. Dykstra; Matthew G. Annis; Ji Dung Luo; Thomas S. Carroll; Caroline S. Jiang; Andrew J. Dannenberg; Peter M. Siegel; Sarah A. Tersey; Raghavendra G. Mirmira; Lawrence Kazak; Paul Cohen

doi:10.1016/j.cmet.2021.01.018

Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer

Olivia A. Maguire
, Sarah E. Ackerman
, Sarah K. Szwed
, Aarthi V. Maganti
, François Marchildon
, Xiaojing Huang
, Daniel J. Kramer
, Adriana Rosas-Villegas
, Rebecca G. Gelfer
, Lauren E. Turner
, Victor Ceballos
, Asal Hejazi
, Bozena Samborska
, Janane F. Rahbani
, Christien B. Dykstra
, Matthew G. Annis
, Ji Dung Luo
, Thomas S. Carroll
, Caroline S. Jiang
, Andrew J. Dannenberg

Peter M. Siegel, Sarah A. Tersey, Raghavendra G. Mirmira, Lawrence Kazak, Paul Cohen

Research output: Contribution to journal › Article › peer-review

124 Scopus citations

Abstract

Obesity is a major risk factor for adverse outcomes in breast cancer. Maguire, Ackerman et al. reveal Gatm and Acsbg1 as molecular regulators of obesity-driven breast cancer progression. They further show that in obesity creatine is a key metabolite in the crosstalk between adipocytes and breast tumors.

Original language	English (US)
Pages (from-to)	499-512.e6
Journal	Cell Metabolism
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/j.cmet.2021.01.018
State	Published - Mar 2 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acsbg1
Gatm
breast cancer
creatine
hypoxia
obesity

Publisher link

10.1016/j.cmet.2021.01.018

Find It

Find It at U of M Libraries

Cite this

Maguire, O. A., Ackerman, S. E., Szwed, S. K., Maganti, A. V., Marchildon, F., Huang, X., Kramer, D. J., Rosas-Villegas, A., Gelfer, R. G., Turner, L. E., Ceballos, V., Hejazi, A., Samborska, B., Rahbani, J. F., Dykstra, C. B., Annis, M. G., Luo, J. D., Carroll, T. S., Jiang, C. S., ... Cohen, P. (2021). Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer. Cell Metabolism, 33(3), 499-512.e6. https://doi.org/10.1016/j.cmet.2021.01.018

Maguire, OA, Ackerman, SE, Szwed, SK, Maganti, AV, Marchildon, F, Huang, X, Kramer, DJ, Rosas-Villegas, A, Gelfer, RG, Turner, LE, Ceballos, V, Hejazi, A, Samborska, B, Rahbani, JF, Dykstra, CB, Annis, MG, Luo, JD, Carroll, TS, Jiang, CS, Dannenberg, AJ, Siegel, PM, Tersey, SA, Mirmira, RG, Kazak, L & Cohen, P 2021, 'Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer', Cell Metabolism, vol. 33, no. 3, pp. 499-512.e6. https://doi.org/10.1016/j.cmet.2021.01.018

@article{fd07172adf964b89a9bdd00c265cc838,

title = "Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer",

abstract = "Obesity is a major risk factor for adverse outcomes in breast cancer. Maguire, Ackerman et al. reveal Gatm and Acsbg1 as molecular regulators of obesity-driven breast cancer progression. They further show that in obesity creatine is a key metabolite in the crosstalk between adipocytes and breast tumors.",

keywords = "Acsbg1, Gatm, breast cancer, creatine, hypoxia, obesity",

author = "Maguire, \{Olivia A.\} and Ackerman, \{Sarah E.\} and Szwed, \{Sarah K.\} and Maganti, \{Aarthi V.\} and Fran{\c c}ois Marchildon and Xiaojing Huang and Kramer, \{Daniel J.\} and Adriana Rosas-Villegas and Gelfer, \{Rebecca G.\} and Turner, \{Lauren E.\} and Victor Ceballos and Asal Hejazi and Bozena Samborska and Rahbani, \{Janane F.\} and Dykstra, \{Christien B.\} and Annis, \{Matthew G.\} and Luo, \{Ji Dung\} and Carroll, \{Thomas S.\} and Jiang, \{Caroline S.\} and Dannenberg, \{Andrew J.\} and Siegel, \{Peter M.\} and Tersey, \{Sarah A.\} and Mirmira, \{Raghavendra G.\} and Lawrence Kazak and Paul Cohen",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2021",

month = mar,

day = "2",

doi = "10.1016/j.cmet.2021.01.018",

language = "English (US)",

volume = "33",

pages = "499--512.e6",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer

AU - Maguire, Olivia A.

AU - Ackerman, Sarah E.

AU - Szwed, Sarah K.

AU - Maganti, Aarthi V.

AU - Marchildon, François

AU - Huang, Xiaojing

AU - Kramer, Daniel J.

AU - Rosas-Villegas, Adriana

AU - Gelfer, Rebecca G.

AU - Turner, Lauren E.

AU - Ceballos, Victor

AU - Hejazi, Asal

AU - Samborska, Bozena

AU - Rahbani, Janane F.

AU - Dykstra, Christien B.

AU - Annis, Matthew G.

AU - Luo, Ji Dung

AU - Carroll, Thomas S.

AU - Jiang, Caroline S.

AU - Dannenberg, Andrew J.

AU - Siegel, Peter M.

AU - Tersey, Sarah A.

AU - Mirmira, Raghavendra G.

AU - Kazak, Lawrence

AU - Cohen, Paul

PY - 2021/3/2

Y1 - 2021/3/2

N2 - Obesity is a major risk factor for adverse outcomes in breast cancer. Maguire, Ackerman et al. reveal Gatm and Acsbg1 as molecular regulators of obesity-driven breast cancer progression. They further show that in obesity creatine is a key metabolite in the crosstalk between adipocytes and breast tumors.

AB - Obesity is a major risk factor for adverse outcomes in breast cancer. Maguire, Ackerman et al. reveal Gatm and Acsbg1 as molecular regulators of obesity-driven breast cancer progression. They further show that in obesity creatine is a key metabolite in the crosstalk between adipocytes and breast tumors.

KW - Acsbg1

KW - Gatm

KW - breast cancer

KW - creatine

KW - hypoxia

KW - obesity

UR - https://www.scopus.com/pages/publications/85101499125

UR - https://www.scopus.com/pages/publications/85101499125#tab=citedBy

U2 - 10.1016/j.cmet.2021.01.018

DO - 10.1016/j.cmet.2021.01.018

M3 - Article

C2 - 33596409

AN - SCOPUS:85101499125

SN - 1550-4131

VL - 33

SP - 499-512.e6

JO - Cell Metabolism

JF - Cell Metabolism

IS - 3

ER -

Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer

Abstract

Bibliographical note

UN SDGs

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this