Cranial irradiation of young rats impairs later learning and growth

J. B. Overmier, M. E. Carroll, R. Patten, W. Krivit, T. H. Kim

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Young rats (26 days) were exposed to ionizing radiation of the head of 0, 1200, 2400, or 3000 rads total in 200 rads/day doses. The subsequent growth of irradiated rats was permanently impaired: such impairment was positively related to amount of irradiation. Beginning in adolescence, rats were trained on a horizontal/vertical visual discrimination in a runway task, and although all four groups mastered the discrimination, they differed in their patterns of acquisition. These results indicate long term effects are associated with a cranial irradiation regimen similar to that given to children suffering acute lymphocytic ieukemia (ALL).

Original languageEnglish (US)
Pages (from-to)179-184
Number of pages6
JournalPhysiology and Behavior
Issue number1
StatePublished - Jul 1979


  • Growth
  • Irradiation
  • Learning
  • Leukemia
  • Radiation
  • X-ray

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