Cracking the O-GlcNAc code in metabolism

Hai Bin Ruan; Jay Prakash Singh; Min Dian Li; Jing Wu; Xiaoyong Yang

doi:10.1016/j.tem.2013.02.002

Cracking the O-GlcNAc code in metabolism

Hai Bin Ruan
, Jay Prakash Singh
, Min Dian Li
, Jing Wu
, Xiaoyong Yang

Integrative Biology and Physiology

Research output: Contribution to journal › Review article › peer-review

203 Scopus citations

Abstract

Nuclear, cytoplasmic, and mitochondrial proteins are extensively modified by O-linked β-. N-acetylglucosamine (. O-GlcNAc) moieties. This sugar modification regulates fundamental cellular processes in response to diverse nutritional and hormonal cues. The enzymes O-GlcNAc transferase (OGT) and O-linked β-. N-acetylglucosaminase (. O-GlcNAcase) mediate the addition and removal of O-GlcNAc, respectively. Aberrant O-GlcNAcylation has been implicated in a plethora of human diseases, including diabetes, cancer, aging, cardiovascular disease, and neurodegenerative disease. Because metabolic dysregulation is a vital component of these diseases, unraveling the roles of O-GlcNAc in metabolism is of emerging importance. Here, we review the current understanding of the functions of O-GlcNAc in cell signaling and gene transcription involved in metabolism, and focus on its relevance to diabetes, cancer, circadian rhythm, and mitochondrial function.

Original language	English (US)
Pages (from-to)	301-309
Number of pages	9
Journal	Trends in Endocrinology and Metabolism
Volume	24
Issue number	6
DOIs	https://doi.org/10.1016/j.tem.2013.02.002
State	Published - Jun 2013

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health (R01 DK089098, P01 DK057751), American Diabetes Association, and Ellison Medical Foundation to X.Y., the Brown-Coxe fellowship to H.R., the China Scholarship Council-Yale World Scholars fellowship to M.L., and the Xi’an Jiaotong University international cooperation grant to J.W.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer metabolism
Circadian rhythm
Hexosamine biosynthesis
Insulin resistance
Mitochondria
O-GlcNAc

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10.1016/j.tem.2013.02.002

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title = "Cracking the O-GlcNAc code in metabolism",

abstract = "Nuclear, cytoplasmic, and mitochondrial proteins are extensively modified by O-linked β-. N-acetylglucosamine (. O-GlcNAc) moieties. This sugar modification regulates fundamental cellular processes in response to diverse nutritional and hormonal cues. The enzymes O-GlcNAc transferase (OGT) and O-linked β-. N-acetylglucosaminase (. O-GlcNAcase) mediate the addition and removal of O-GlcNAc, respectively. Aberrant O-GlcNAcylation has been implicated in a plethora of human diseases, including diabetes, cancer, aging, cardiovascular disease, and neurodegenerative disease. Because metabolic dysregulation is a vital component of these diseases, unraveling the roles of O-GlcNAc in metabolism is of emerging importance. Here, we review the current understanding of the functions of O-GlcNAc in cell signaling and gene transcription involved in metabolism, and focus on its relevance to diabetes, cancer, circadian rhythm, and mitochondrial function.",

keywords = "Cancer metabolism, Circadian rhythm, Hexosamine biosynthesis, Insulin resistance, Mitochondria, O-GlcNAc",

author = "Ruan, \{Hai Bin\} and Singh, \{Jay Prakash\} and Li, \{Min Dian\} and Jing Wu and Xiaoyong Yang",

note = "Funding Information: This work was supported by the National Institutes of Health (R01 DK089098, P01 DK057751), American Diabetes Association, and Ellison Medical Foundation to X.Y., the Brown-Coxe fellowship to H.R., the China Scholarship Council-Yale World Scholars fellowship to M.L., and the Xi{\textquoteright}an Jiaotong University international cooperation grant to J.W.",

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doi = "10.1016/j.tem.2013.02.002",

language = "English (US)",

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AU - Singh, Jay Prakash

AU - Li, Min Dian

AU - Wu, Jing

AU - Yang, Xiaoyong

N1 - Funding Information: This work was supported by the National Institutes of Health (R01 DK089098, P01 DK057751), American Diabetes Association, and Ellison Medical Foundation to X.Y., the Brown-Coxe fellowship to H.R., the China Scholarship Council-Yale World Scholars fellowship to M.L., and the Xi’an Jiaotong University international cooperation grant to J.W.

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N2 - Nuclear, cytoplasmic, and mitochondrial proteins are extensively modified by O-linked β-. N-acetylglucosamine (. O-GlcNAc) moieties. This sugar modification regulates fundamental cellular processes in response to diverse nutritional and hormonal cues. The enzymes O-GlcNAc transferase (OGT) and O-linked β-. N-acetylglucosaminase (. O-GlcNAcase) mediate the addition and removal of O-GlcNAc, respectively. Aberrant O-GlcNAcylation has been implicated in a plethora of human diseases, including diabetes, cancer, aging, cardiovascular disease, and neurodegenerative disease. Because metabolic dysregulation is a vital component of these diseases, unraveling the roles of O-GlcNAc in metabolism is of emerging importance. Here, we review the current understanding of the functions of O-GlcNAc in cell signaling and gene transcription involved in metabolism, and focus on its relevance to diabetes, cancer, circadian rhythm, and mitochondrial function.

AB - Nuclear, cytoplasmic, and mitochondrial proteins are extensively modified by O-linked β-. N-acetylglucosamine (. O-GlcNAc) moieties. This sugar modification regulates fundamental cellular processes in response to diverse nutritional and hormonal cues. The enzymes O-GlcNAc transferase (OGT) and O-linked β-. N-acetylglucosaminase (. O-GlcNAcase) mediate the addition and removal of O-GlcNAc, respectively. Aberrant O-GlcNAcylation has been implicated in a plethora of human diseases, including diabetes, cancer, aging, cardiovascular disease, and neurodegenerative disease. Because metabolic dysregulation is a vital component of these diseases, unraveling the roles of O-GlcNAc in metabolism is of emerging importance. Here, we review the current understanding of the functions of O-GlcNAc in cell signaling and gene transcription involved in metabolism, and focus on its relevance to diabetes, cancer, circadian rhythm, and mitochondrial function.

KW - Cancer metabolism

KW - Circadian rhythm

KW - Hexosamine biosynthesis

KW - Insulin resistance

KW - Mitochondria

KW - O-GlcNAc

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DO - 10.1016/j.tem.2013.02.002

M3 - Review article

C2 - 23647930

AN - SCOPUS:84878235671

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VL - 24

SP - 301

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JF - Trends in Endocrinology and Metabolism

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ER -

Cracking the O-GlcNAc code in metabolism

Abstract

Bibliographical note

UN SDGs

Keywords

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