COVID-19 convalescent plasma

Aaron A.R. Tobian, Claudia S. Cohn, Beth H. Shaz

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


As the coronavirus disease (COVID-19) pandemic led to a global health crisis, there were limited treatment options and no prophylactic therapies for those exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Convalescent plasma is quick to implement, potentially provides benefits, and has a good safety profile. The therapeutic potential of COVID-19 convalescent plasma (CCP) is likely mediated by antibodies through direct viral neutralization and Fc-dependent functions such as a phagocytosis, complement activation, and antibody-dependent cellular cytotoxicity. In the United States, CCP became one of the most common treatments with more than a half million units transfused despite limited efficacy data. More than a dozen randomized trials now demonstrate that CCP does not provide benefit for those hospitalized with moderate to severe disease. However, similar to other passive antibody therapies, CCP is beneficial for early disease when provided to elderly outpatients within 72 hours after symptom onset. Only high-titer CCP should be transfused. CCP should also be considered for immunosuppressed patients with COVID-19. CCP collected in proximity, by time and location, to the patient may be more beneficial because of SARS-CoV-2 variants. Additional randomized trial data are still accruing and should be incorporated with other trial data to optimize CCP indications.

Original languageEnglish (US)
Pages (from-to)196-207
Number of pages12
Issue number3
StatePublished - Jul 21 2022

Bibliographical note

Funding Information:
The authors thank Bill Block, Jennifer Kapral, and Joshua Xianming Zhu for assistance with Figure 1.

Publisher Copyright:
© 2022 American Society of Hematology

PubMed: MeSH publication types

  • Journal Article


Dive into the research topics of 'COVID-19 convalescent plasma'. Together they form a unique fingerprint.

Cite this