Coversyl Plus - Treating hypertension and improving clinical outcomes in T2D and other high risk groups

  • Katherine Croom
  • , George Kassianos
  • , Michael Schachter
  • , Jonathan Morrell
  • , Allan Gaw
  • , Michael Kirby
  • , Juan Tamargo
  • , Barbara Yawn
  • , Roy Yawn
  • , Khalid Barakat
  • , Pam Brown
  • , Jamie Dalrymple
  • , Kurt Elward
  • , Ted Ganiats
  • , David Halpin
  • , Mike LeFevre
  • , Frederick North
  • , David Price
  • , Jill Rasmussen
  • , Steven Spann
  • Richard Stevens, Alfred F. Tallia, Don Uden, Marion Waite, Derek Waller

Research output: Contribution to journalArticlepeer-review

Abstract

Many patients with hypertension require combination therapy to reduce their blood pressure to target levels. Treatment with an angiotensin-converting enzyme (ACE) inhibitor such as perindopril, plus a diuretic such as indapamide, is frequently used to control hypertension. Coversyl Plus combines perindopril, 4 mg, and indapamide, 1.25 mg, in a single tablet, taken once daily, and thus can simplify treatment schedules and increase patient compliance. Coversyl Plus can reduce blood pressure to a greater extent than monotherapy with some other antihypertensive agents, and to an equivalent extent to certain other combination regimens. Results from a recent, large-scale clinical outcomes study have also shown that Coversyl Plus reduces the risk of premature death, micro- and macrovascular outcomes, and renal outcomes (such as the development of microalbuminuria) in hypertensive patients with type 2 diabetes. Importantly, these benefits appear to be independent of a range of treatments and the presence or absence of hypertension at baseline. Coversyl Plus is associated with an excellent safety and tolerability profile, and thus remains a valuable treatment option for hypertension. In addition, Coversyl Plus has been shown to be of particular benefit in significantly reducing risk in hypertensive patients with type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)71-84
Number of pages14
JournalDrugs in Context
Volume4
Issue number1
StatePublished - 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Antihypertensive
  • Coversyl Plus
  • Hypertension
  • Indapamide
  • Perindopril

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