Covalent and Noncovalent Modification of Thin Filament Action: The Essential Role of Troponin in Cardiac Muscle Regulation

Joseph M. Metzger, Margaret V. Westfall

Research output: Contribution to journalReview articlepeer-review

140 Scopus citations

Abstract

Troponin is essential for the regulation of cardiac contraction. Troponin is a sarcomeric molecular switch, directly regulating the contractile event in concert with intracellular calcium signals. Troponin isoform switching, missense mutations, proteolytic cleavage, and posttranslational modifications are known to directly affect sarcomeric regulation. This review focuses on physiologically relevant covalent and noncovalent modifications in troponin as part of a thematic series on cardiac thin filament function in health and disease.

Original languageEnglish (US)
Pages (from-to)146-158
Number of pages13
JournalCirculation research
Volume94
Issue number2
DOIs
StatePublished - Feb 6 2004

Keywords

  • Calcium
  • Contractility
  • Myocardium
  • Phosphorylation

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