Coupling of the TCR to integrin activation by SLAP-130/Fyb

E. J. Peterson; M. L. Woods; S. A. Dmowski; G. Derimanov; M. S. Jordan; J. N. Wu; P. S. Myung; Q. H. Liu; J. T. Pribila; B. D. Freedman; Y. Shimizu; G. A. Koretzky

doi:10.1126/science.1063486

Coupling of the TCR to integrin activation by SLAP-130/Fyb

E. J. Peterson, M. L. Woods, S. A. Dmowski, G. Derimanov, M. S. Jordan, J. N. Wu, P. S. Myung, Q. H. Liu, J. T. Pribila, B. D. Freedman, Y. Shimizu, G. A. Koretzky

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Abstract

SLAP-130/Fyb (SLP-76-associated phosphoprotein or Fyn-binding protein; also known as Fyb/Slap) is a hematopoietic-specific adapter, which associates with and modulates function of SH2-containing leukocyte phosphoprotein of 76 kilodaltons (SLP-76). T cells from mice lacking SLAP-130/Fyb show markedly impaired proliferation following CD3 engagement. In addition, the T cell receptor (TCR) in SLAP-130/Fyb mutant cells fails to enhance integrin-dependent adhesion. Although TCR-induced actin polymerization is normal TCR-stimulated clustering of the integrin LFA-1 is defective in SLAP-130/Fyb-deficient cells. These data indicate that SLAP-130/Fyb is important for coupling TCR-mediated actin cytoskeletal rearrangement with activation of integrin function, and for T cells to respond fully to activating signals.

Original language	English (US)
Pages (from-to)	2263-2265
Number of pages	3
Journal	Science
Volume	293
Issue number	5538
DOIs	https://doi.org/10.1126/science.1063486
State	Published - Sep 21 2001

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title = "Coupling of the TCR to integrin activation by SLAP-130/Fyb",

abstract = "SLAP-130/Fyb (SLP-76-associated phosphoprotein or Fyn-binding protein; also known as Fyb/Slap) is a hematopoietic-specific adapter, which associates with and modulates function of SH2-containing leukocyte phosphoprotein of 76 kilodaltons (SLP-76). T cells from mice lacking SLAP-130/Fyb show markedly impaired proliferation following CD3 engagement. In addition, the T cell receptor (TCR) in SLAP-130/Fyb mutant cells fails to enhance integrin-dependent adhesion. Although TCR-induced actin polymerization is normal TCR-stimulated clustering of the integrin LFA-1 is defective in SLAP-130/Fyb-deficient cells. These data indicate that SLAP-130/Fyb is important for coupling TCR-mediated actin cytoskeletal rearrangement with activation of integrin function, and for T cells to respond fully to activating signals.",

author = "Peterson, {E. J.} and Woods, {M. L.} and Dmowski, {S. A.} and G. Derimanov and Jordan, {M. S.} and Wu, {J. N.} and Myung, {P. S.} and Liu, {Q. H.} and Pribila, {J. T.} and Freedman, {B. D.} and Y. Shimizu and Koretzky, {G. A.}",

year = "2001",

month = sep,

day = "21",

doi = "10.1126/science.1063486",

language = "English (US)",

volume = "293",

pages = "2263--2265",

journal = "Science",

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T1 - Coupling of the TCR to integrin activation by SLAP-130/Fyb

AU - Peterson, E. J.

AU - Woods, M. L.

AU - Dmowski, S. A.

AU - Derimanov, G.

AU - Jordan, M. S.

AU - Wu, J. N.

AU - Myung, P. S.

AU - Liu, Q. H.

AU - Pribila, J. T.

AU - Freedman, B. D.

AU - Shimizu, Y.

AU - Koretzky, G. A.

PY - 2001/9/21

Y1 - 2001/9/21

N2 - SLAP-130/Fyb (SLP-76-associated phosphoprotein or Fyn-binding protein; also known as Fyb/Slap) is a hematopoietic-specific adapter, which associates with and modulates function of SH2-containing leukocyte phosphoprotein of 76 kilodaltons (SLP-76). T cells from mice lacking SLAP-130/Fyb show markedly impaired proliferation following CD3 engagement. In addition, the T cell receptor (TCR) in SLAP-130/Fyb mutant cells fails to enhance integrin-dependent adhesion. Although TCR-induced actin polymerization is normal TCR-stimulated clustering of the integrin LFA-1 is defective in SLAP-130/Fyb-deficient cells. These data indicate that SLAP-130/Fyb is important for coupling TCR-mediated actin cytoskeletal rearrangement with activation of integrin function, and for T cells to respond fully to activating signals.

AB - SLAP-130/Fyb (SLP-76-associated phosphoprotein or Fyn-binding protein; also known as Fyb/Slap) is a hematopoietic-specific adapter, which associates with and modulates function of SH2-containing leukocyte phosphoprotein of 76 kilodaltons (SLP-76). T cells from mice lacking SLAP-130/Fyb show markedly impaired proliferation following CD3 engagement. In addition, the T cell receptor (TCR) in SLAP-130/Fyb mutant cells fails to enhance integrin-dependent adhesion. Although TCR-induced actin polymerization is normal TCR-stimulated clustering of the integrin LFA-1 is defective in SLAP-130/Fyb-deficient cells. These data indicate that SLAP-130/Fyb is important for coupling TCR-mediated actin cytoskeletal rearrangement with activation of integrin function, and for T cells to respond fully to activating signals.

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ER -

Coupling of the TCR to integrin activation by SLAP-130/Fyb

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