Coupling of the TCR to integrin activation by SLAP-130/Fyb

E. J. Peterson, M. L. Woods, S. A. Dmowski, G. Derimanov, M. S. Jordan, J. N. Wu, P. S. Myung, Q. H. Liu, J. T. Pribila, B. D. Freedman, Y. Shimizu, G. A. Koretzky

Research output: Contribution to journalArticlepeer-review

271 Scopus citations


SLAP-130/Fyb (SLP-76-associated phosphoprotein or Fyn-binding protein; also known as Fyb/Slap) is a hematopoietic-specific adapter, which associates with and modulates function of SH2-containing leukocyte phosphoprotein of 76 kilodaltons (SLP-76). T cells from mice lacking SLAP-130/Fyb show markedly impaired proliferation following CD3 engagement. In addition, the T cell receptor (TCR) in SLAP-130/Fyb mutant cells fails to enhance integrin-dependent adhesion. Although TCR-induced actin polymerization is normal TCR-stimulated clustering of the integrin LFA-1 is defective in SLAP-130/Fyb-deficient cells. These data indicate that SLAP-130/Fyb is important for coupling TCR-mediated actin cytoskeletal rearrangement with activation of integrin function, and for T cells to respond fully to activating signals.

Original languageEnglish (US)
Pages (from-to)2263-2265
Number of pages3
Issue number5538
StatePublished - Sep 21 2001


Dive into the research topics of 'Coupling of the TCR to integrin activation by SLAP-130/Fyb'. Together they form a unique fingerprint.

Cite this