Cost-effectiveness of pravastatin therapy for survivors of myocardial infarction with average cholesterol levels

Joel Tsevat, Karen M. Kuntz, E. John Orav, Milton C. Weinstein, Frank M. Sacks, Lee Goldman

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

Background: The objective of this study was to assess the cost-effectiveness of pravastatin therapy in survivors of myocardial infarction with average cholesterol levels. Methods: We performed a cost-effectiveness analysis based on actual clinical, cost, and health-related quality-of-life data from the Cholesterol and Recurrent Events (CARE) trial. Survival and recurrent coronary heart disease events were modeled from trial data in Markov models, with the use of different assumptions regarding the long-term benefit of therapy. Results: Pravastatin therapy increased quality-adjusted life expectancy at an incremental cost of $16,000 to $32,000 per quality-adjusted life-year gained. In subgroup analyses, the cost-effectiveness of pravastatin therapy was more favorable for patients >60 years of age and for patients with pretreatment low-density lipoprotein cholesterol levels >125 mg/dL. Results were sensitive to the cost of pravastatin and to assumptions about long-term survival benefits from pravastatin therapy. Conclusions: The cost-effectiveness of pravastatin therapy in survivors of myocardial infarction with average cholesterol levels compares favorably with other interventions.

Original languageEnglish (US)
Pages (from-to)727-734
Number of pages8
JournalAmerican Heart Journal
Volume141
Issue number5
DOIs
StatePublished - Jan 1 2001

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