Cost-effectiveness at two years in the VA open versus endovascular repair trial

F. A. Lederle, K. T. Stroupe

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Background: Long-term clinical outcomes have been similar for endovascular and open repair of abdominal aortic aneurysm (AAA), increasing the importance of comparing cost-effectiveness. Methods: We compared data to two years from a multicenter randomized trial of 881 patients. Quality-adjusted life years (QALYs) were calculated from EQ-5D questionnaires. Healthcare utilization data were obtained from patients and from national VA and Medicare sources. VA costs were obtained using methods previously developed by the VA Health Economics Resource Center. Costs for non-VA care were determined from Medicare or billing data. Results: Mean life-years were 1.78 in the endovascular and 1.74 in the open repair group (P = 0.29), and mean QALYs were 1.462 in the endovascular and 1.461 in the open group (P = 0.78). Although graft costs were higher in the endovascular group ($14,052 vs. $1363; P < 0.001), length of stay was shorter (5.0 vs. 10.5 days; P < 0.001), resulting in lower cost of AAA repair hospitalization in the endovascular group ($37,068 vs. $42,970; P = 0.04). Costs remained lower after 2 years in the endovascular group but the difference was no longer significant (-$5019; 95% CI: -$16,720 to $4928; P = 0.35). The probability that endovascular repair was both more effective and less costly was 70.9% for life-years and 51.4% for QALYs. Interpretation: Endovascular repair is a cost-effective alternative to open repair in the US VA healthcare system for at least the first two years.

Original languageEnglish (US)
Pages (from-to)543-548
Number of pages6
JournalEuropean Journal of Vascular and Endovascular Surgery
Issue number6
StatePublished - Dec 2012

Bibliographical note

Funding Information:
Supported by the Cooperative Studies Program of the Department of Veterans Affairs (VA) Office of Research and Development, Washington, D.C.


  • Abdominal aortic aneurysm
  • Cost effectiveness
  • Department of Veterans Affairs
  • Quality of life
  • Randomized trials


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