Cosinor analysis of 24-hour blood pressure profile in hypertensives before and after treatment with ACE-inhibitor enalapril

J. Siegelova, B. Fiser, J. Dusek, G. Cornelissen, F. Halberg

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of the study was to evaluate the efficiency of the antihypertensive treatment with ACE-inhibitor enalapril in patients with essential hypertension by means of 24-hours ambulatory blood pressure monitoring. Eleven patients were examined after 2 weeks of placebo therapy and after 4 weeks of enalapril (Enalapril Lachema, 12.4 ± 4.1 mg, one day dosis) therapy. For the evaluation of the circadian variation of measured values a single cosinor and population cosinor analysis was used. Enalapril therapy significantly decreased MESOR in systolic (p = 0.03) and diastolic blood pressure (p = 0.02) but not the amplitude and acrophase.

Original languageEnglish (US)
Pages (from-to)203-206
Number of pages4
JournalEurorehab
Issue number4
StatePublished - Dec 1 1995

Keywords

  • Ambulatory blood pressure monitoring
  • Cosinor analysis
  • Enalapril
  • Essential hypertension

Fingerprint Dive into the research topics of 'Cosinor analysis of 24-hour blood pressure profile in hypertensives before and after treatment with ACE-inhibitor enalapril'. Together they form a unique fingerprint.

Cite this