Cortisol measures in primary major depressive disorder with hypersomnia or appetite increase

Regina C. Casper, James Kocsis, Maurice Dysken, Peter Stokes, Jack Croughan, James Maas

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Morning plasma cortisol response to the 1 mg dexamethasone suppression test along with cortisol levels in blood, cerebrospinal fluid (CSF), and urine were measured in hospitalized male and female patients with primary major depressive disorder who reported hypersomnia (n=23), or increase in appetite (n=22). Comparisons were drawn to cortisol levels in patients with primary major depressive disorder who did not report hypersomnia or appetite increase (n=23) and to normal controls (n=23), all age- and sex-matched. Depressives with hypersomnia or increased appetite showed higher than normal 24-h urinary free cortisol concentrations. Depressed patients without hypersomnia or appetite increase had in addition to elevated free urinary cortisol concentrations higher than normal morning plasma cortisol levels before and after dexamethasone administration and a higher incidence of cortisol non-supression after dexamethasone compared to normal subjects. The findings provide preliminary evidence that HPA activation in depression is diminished in the presence of hypersomnia and/or an increased appetite. Studies of the hypothalamic-pituitary-adrenal axis may be useful for differentiating subtypes of depression characterized by hypersomnia or enhanced appetite.

Original languageEnglish (US)
Pages (from-to)131-140
Number of pages10
JournalJournal of Affective Disorders
Volume15
Issue number2
DOIs
StatePublished - 1988

Keywords

  • Appetite increase
  • Cortisol levels
  • Hypersomnia
  • Major depressive disorder

Fingerprint Dive into the research topics of 'Cortisol measures in primary major depressive disorder with hypersomnia or appetite increase'. Together they form a unique fingerprint.

Cite this