Corticostriatal interactions during learning, memory processing, and decision making

Cyriel M.A. Pennartz, Joshua D. Berke, Ann M. Graybiel, Rutsuko Ito, Carien S. Lansink, Matthijs Van Der Meer, A. David Redish, Kyle S. Smith, Pieter Voorn

    Research output: Contribution to journalArticlepeer-review

    140 Scopus citations

    Abstract

    This mini-symposium aims to integrate recent insights from anatomy, behavior, and neurophysiology, highlighting the anatomical organization, behavioral significance, and information-processing mechanisms of corticostriatal interactions. In this summary of topics, which is not meant to provide a comprehensive survey, we will first review the anatomy of corticostriatal circuits, comparing different ways by which "loops" of cortical- basal ganglia circuits communicate. Next, we will address the causal importance and systems-neurophysiological mechanisms of corticostriatal interactions for memory, emphasizing the communication between hippocampus and ventral striatum during contextual conditioning. Furthermore, ensemble recording techniques have been applied to compare information processing in the dorsal and ventral striatum to predictions from reinforcement learning theory. We will next discuss how neural activity develops in corticostriatal areas when habits are learned. Finally, we will evaluate the role of GABAergic interneurons in dynamically transforming cortical inputs into striatal output during learning and decision making.

    Original languageEnglish (US)
    Pages (from-to)12831-12838
    Number of pages8
    JournalJournal of Neuroscience
    Volume29
    Issue number41
    DOIs
    StatePublished - Oct 14 2009

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