Corticospinal excitability in children with congenital hemiparesis

Chao Ying Chen, Tonya L. Rich, Jessica M. Cassidy, Bernadette T. Gillick

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Transcranial magnetic stimulation (TMS) can be used as an assessment or intervention to evaluate or influence brain activity in children with hemiparetic cerebral palsy (CP) commonly caused by perinatal stroke. This communication report analyzed data from two clinical trials using TMS to assess corticospinal excitability in children and young adults with hemiparetic CP. The results of this communication revealed a higher probability of finding a motor evoked potential (MEP) on the non-lesioned hemisphere compared to the lesioned hemisphere (p = 0.005). The resting motor threshold (RMT) was lower on the non-lesioned hemisphere than the lesioned hemisphere (p = 0.013). There was a significantly negative correlation between age and RMT (rs = -0.65, p = 0.003). This communication provides information regarding MEP responses, motor thresholds (MTs) and the association with age during TMS assessment in children with hemiparetic CP. Such findings contribute to the development of future pediatric studies in neuroplasticity and neuromodulation to influence motor function and recovery after perinatal stroke.

Original languageEnglish (US)
Article number49
JournalBrain Sciences
Issue number4
StatePublished - Dec 2016

Bibliographical note

Funding Information:
We thank the families and children who participated in these two clinical trials. We also acknowledge the funding support by National Institute of Health (NIH) (1RC1HD063838-01), National Center for Research Resources (1UL1RR033183-01), National Center for Advancing Translational Sciences of the NIH (8 UL1 TR000114-02) to the University of Minnesota Clinical and Translational Science Institute (CTSI), the NIH Eunice Kennedy Shriver National Institutes of Child Health and Development K01 Award (#HD078484-01A1), the Cerebral Palsy Foundation, the Foundation for Physical Therapy Magistro Family Grant, and MnDRIVE brain condition fellowships.

Publisher Copyright:
© 2016 by the authors; licensee MDPI, Basel, Switzerland.


  • Cerebral palsy
  • Motor evoked potential
  • Motor threshold
  • Perinatal stroke
  • Transcranial magnetic stimulation


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