Cortical miscommunication after prenatal exposure to alcohol

Scott M. Lewis, Rosa R. Vydrová, Arthur C. Leuthold, Apostolos P. Georgopoulos

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

We report on the effects of prenatal alcohol exposure on resting-state brain activity as measured by magnetoencephalography (MEG). We studied 37 subjects diagnosed with fetal alcohol spectrum disorder in one of three categories: fetal alcohol syndrome, partial fetal alcohol syndrome, and alcohol-related neurodevelopmental disorder. For each subject, the MEG signal was recorded for 60 s during rest while subjects lay supine. Using time series analysis, we calculated the synchronous neural interactions for all pair-wise combinations of 248 MEG sensors resulting in 30,628 partial correlations for each subject. We found significant differences from control subjects in 6.19 % of the partial zero-lag crosscorrelations (synchronous neural interactions; Georgopoulos et al. in J Neural Eng 4:349–355, 2007), with these differences localized in the right posterior frontal, right parietal, and left parietal/posterior frontal regions. These results show that MEG can detect functional brain differences in the individuals affected by prenatal exposure to alcohol. Furthermore, these differences may serve as a biomarker for future studies linking symptoms and signs to specific brain areas. This may lead to new insights into the neuropathology of fetal alcohol spectrum disorders.

Original languageEnglish (US)
Pages (from-to)3347-3353
Number of pages7
JournalExperimental Brain Research
Volume234
Issue number11
DOIs
StatePublished - Nov 1 2016

Bibliographical note

Funding Information:
This work was supported by the Department of Veterans Affairs, and the American Legion Brain Sciences Chair. R.R.V. was supported by a Fellowship form the Department of Pediatric Neurology, Charles University, 2nd Faculty of Medicine, University Hospital Motol, Prague, Czech Republic.

Publisher Copyright:
© 2016, Springer-Verlag Berlin Heidelberg (outside the USA).

Keywords

  • Fetal alcohol syndrome
  • Magnetoencephalography
  • Resting state
  • Synchronous neural interactions

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