Cortical gray matter volume deficits in schizophrenia: A replication

Kelvin O. Lim, Edith V. Sullivan, Robert B. Zipursky, Adolf Pfefferbaum

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


We sought to replicate an earlier finding of widespread deficit in cortical gray matter in schizophrenia by testing new samples of 22 schizophrenic patients and 27 controls between the ages of 21-46 years. Brain values for both patients and controls were standardized against age and head size norms derived from a larger control group (n = 73) spanning a wider age range (21-70). Compared to the new age-matched controls, the new schizophrenic sample showed a deficit in gray matter volume affecting the cortex as a whole and enlargement of the lateral and third ventricles. Thus, widespread cortical gray matter deficit is a replicable feature of the brain dysmorphology of schizophrenia in young to middle-aged men.

Original languageEnglish (US)
Pages (from-to)157-164
Number of pages8
JournalSchizophrenia Research
Issue number1-2
StatePublished - May 1996

Bibliographical note

Funding Information:
This work was supported by grants from the National Institute of Mental Health (NIMH 30854) and the Medical Research Service of the Department of Veterans Affairs.


  • MRI
  • brain
  • cortical gray matter
  • replication
  • schizophrenia
  • ventricles

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