Corrigendum to “Physiologic Adaptation to Macronutrient Change Distorts Findings from Short Dietary Trials: Reanalysis of a Metabolic Ward Study” [J Nutr 154 (2024) 1080–1086] (The Journal of Nutrition (2024) 154(3) (1061–1063), (S0022316624000452), (10.1016/j.tjnut.2024.01.026))

  • Adrian Soto-Mota
  • , Lisa T. Jansen
  • , Nicholas G. Norwitz
  • , Mark A. Pereira
  • , Cara B. Ebbeling
  • , David S. Ludwig

Research output: Contribution to journalComment/debatepeer-review

Abstract

An error in a statistical model that treated each day as an independent datapoint and involving several descriptive analyses resulted in incorrect P-values, as considered in our recent Letter to the Editor (1). Correct P-values using linear regression are as follows: • Energy intake on the low-carbohydrate diet: Figure 1A and associated text, P = 0.02.• Energy intake on the low-fat diet: Figure 1B and associated text, P = 0.007.• Change in body fat on the low-carbohydrate diet: Figure 2A and associated text, P = 0.04.• β-hydroxybutyrate: Figure 3A and associated text (with elimination of 1 outlier, 3x above the upper limit of the interquartile range), P = 0.04.• Respiratory quotient: Figure 3B and associated text, P = 0.09.• For the unbiased but underpowered comparisons in the first treatment period showing numerical advantages for the low-carbohydrate diet, energy intake in week 2 without and with baseline BMI adjustment: P = 0.11 and 0.10, respectively.• On page 5, column 2, the second sentence should read: “An unbiased but underpowered test of energy intake limited to week 2 of the first diet period (i.e., after 1 week of metabolic adaptation), showed a numerically large although statistically non-significant advantage for the LCD (521 kcal/d less energy intake).”This error does not affect our calculation of the carry-over effect or the main conclusions of our paper. We apologize for any inconvenience.

Original languageEnglish (US)
Pages (from-to)1486
Number of pages1
JournalJournal of Nutrition
Volume154
Issue number4
DOIs
StatePublished - Apr 2024

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