Correlation of plasma protein C levels with cardiovascular risk factors in middle-aged adults: The atherosclerosis risk in communities (ARIC) study

M. G. Conlan, A. R. Folsom, A. Finch, C. E. Davis, P. Sorlie, K. K. Wu

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

To evaluate the association of plasma protein C levels with constitutional, socioeconomic, life-style and biochemical factors important in cardiovascular diseases, we measured protein C levels in 12,290 middle aged (45-64 years) subjects participating in the ARIC study. Protein C levels had a normal distribution with a mean value of 3.17 μg/ml. They were higher in women than men and in whites than blacks; higher in postmenopausal women and further increased by hormonal supplements. The age influence was inconsistent and was considered to be inconsequential. Protein C levels were positively correlated with body mass index, LDL-cholesterol, HDL-cholesterol, and triglycerides and negatively associated with cigarette smoking. These factors should be taken into consideration when establishing normal protein C levels and when analyzing the relation between protein C and arterial and venous thrombotic disorders.

Original languageEnglish (US)
Pages (from-to)762-767
Number of pages6
JournalThrombosis and Haemostasis
Volume70
Issue number5
DOIs
StatePublished - 1993

Fingerprint Dive into the research topics of 'Correlation of plasma protein C levels with cardiovascular risk factors in middle-aged adults: The atherosclerosis risk in communities (ARIC) study'. Together they form a unique fingerprint.

Cite this