Correlation of Foxp3 positive regulatory T cells with prognostic factors in canine mammary carcinomas

J. H. Kim, J. H. Hur, S. M. Lee, K. S. Im, N. H. Kim, J. H. Sur

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Regulatory T cells (Treg) cells play a crucial role in tumor progression by suppressing anti-tumor immunity, but are not well-documented in veterinary oncology. To identify the characteristics of Treg cells in tumor microenvironments, the numbers of Treg cells were analyzed and compared with histological prognostic factors and molecular biomarkers in canine mammary carcinoma (MC) tissues (n= 37).Abundant Treg cells were associated with high histological grade and lymphatic invasion. The numbers of Treg cells infiltrating intratumoral areas markedly increased in tumors with poor prognostic factors, such as high histological grade, lymphatic invasion, and necrosis. These findings suggest that Treg cells play a role in canine MC progression. Furthermore, Treg cell numbers in intratumoral compartments may provide a potential prognostic factor when assessing canine MCs, which may in turn lead to the development of new immunologic therapeutics.

Original languageEnglish (US)
Pages (from-to)222-227
Number of pages6
JournalVeterinary Journal
Issue number1
StatePublished - Jul 2012
Externally publishedYes

Bibliographical note

Funding Information:
We would like to thank Ms. R.H. Jang for her excellent technical assistance and private animal clinics for providing canine mammary samples. J.H. Hur contributed equally to this paper with the first author. This report represents one part of a PhD thesis by J.H. Hur. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (20110021337).


  • Dog
  • Foxp3
  • Mammary carcinoma
  • Prognostic factor
  • Regulatory T cell


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