Correlation of brain Magnetic Resonance Imaging of spontaneously lead poisoned bald eagles (Haliaeetus leucocephalus) with histological lesions: A pilot study

Olga Nicolas de Francisco, Daniel Feeney, Anibal G. Armién, Arno Wuenschmann, Patrick T. Redig

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Six bald eagles with severe, acute lead poisoning based on blood lead values were analyzed by Magnetic Resonance Imaging (MRI) of the brain and histopathology. The aims of the study were to use MRI to locate brain lesions and correlate the changes in MRI signal with the histological character of the lesions at necropsy. All of the bald eagles presented with neurologic and non-neurologic signs suggestive of severe lead poisoning and had blood lead levels in excess of 1.0 ppm. Areas of change in image intensity in the brainstem, midbrain and cerebellum were detected in the MRI scans. Histopathology confirmed the presence of all suspected lesions. The character of the lesions suggested vascular damage as the primary insult. MRI was useful for detecting lesions and defining their three-dimensional distribution and extent. Future studies are needed to evaluate the utility of MRI for detection of lesions in less severely lead poisoned eagles and determining prognosis for treatment.

Original languageEnglish (US)
Pages (from-to)236-242
Number of pages7
JournalResearch in veterinary science
Volume105
DOIs
StatePublished - Apr 1 2016

Bibliographical note

Funding Information:
This project was supported by funds from the Association of Avian Veterinarians and they had no involvement in the design or execution of the study.

Publisher Copyright:
© 2016 Elsevier Ltd.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

  • Brain
  • Eagle
  • Intoxication
  • Lead
  • Magnetic Resonance Imaging (MRI)
  • Pathology

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