Correlation of activation sizes between lateral geniculate nucleus and primary visual cortex in humans

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Abstract

It is well established that the lateral geniculate nucleus (LGN) and the primary visual cortex (V1) are retinotopically organized. This similarity is expected to reflect a correlation of activation sizes between V1 and LGN during visual stimulation. However, it is a challenge to determine this functional correlation experimentally in the human brain using most neuroimaging techniques due to their low sensitivity for detecting small LGN activation in the thalamus. The purpose of this study was to examine the functional correlation of activation sizes between LGN and V1 during fullfield and hemifield visual stimulation using a large visual field and high-resolution fMRI technique at 4 Tesla. The correlation was determined by comparing the V1 and LGN activation size ratios between the left and right hemispheres of the same subjects. The results reveal 1) a linear correlation of functional activation size ratio between LGN and V1 with a correlation coefficient of 0.96, and 2) the capability of fMRI for quantifying spatial correlation between cortical and subcortical activation.

Original languageEnglish (US)
Pages (from-to)202-205
Number of pages4
JournalMagnetic resonance in medicine
Volume45
Issue number2
DOIs
StatePublished - 2001

Keywords

  • Activation correlation
  • Functional MRI
  • High magnetic field
  • High-resolution fMRI
  • Human brain
  • Lateral geniculate nucleus
  • Neural activity
  • Neural network
  • Primary visual cortex
  • Visual system

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