Correlation of a T45S variant of apolipoprotein C1 with elevated BMI in persons of American Indian and Mexican ancestries

R. S. Kasthuri, K. R. McMillan, C. Flood-Urdangarin, S. B. Harvey, J. T. Wilson-Grady, G. L. Nelsestuen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Obesity and diabetes are serious health problems for Americans and especially for those with American Indian or Mexican ancestry. A preliminary survey by protein analysis rather than classical nucleic acid sequencing methods has suggested a correlation between a newly discovered T45S variant of apolipoprotein C1 (ApoC1), found only in persons with American Indian or Mexican ancestry, and elevated body mass index (BMI). American Indians with the S45 ApoC1 variant (n=36) had an average of 9% higher BMI than those who had only T45 ApoC1 (n=192, P=0.029). Elevated rates of diabetes were reported for parents of subjects with the S45 protein (P=0.006). In five gender-matched sibling pairs, persons with Mexican ancestry showed a 1.34-fold higher BMI for those with S45 ApoC1 (P=0.022). This protein may contribute to the elevated rates of diabetes in relevant ethnic groups and might be more common in isolated populations.

Original languageEnglish (US)
Pages (from-to)1334-1336
Number of pages3
JournalInternational Journal of Obesity
Volume31
Issue number8
DOIs
StatePublished - Aug 1 2007

Fingerprint

Apolipoprotein C-I
apolipoproteins
North American Indians
American Indians
body mass index
ancestry
Body Mass Index
diabetes
Proteins
proteins
nationalities and ethnic groups
Ethnic Groups
Nucleic Acids
nucleic acids
Siblings
obesity
Obesity
Parents
gender
Health

Keywords

  • American Indian
  • Apoliprotein C1
  • Mexican American

Cite this

Correlation of a T45S variant of apolipoprotein C1 with elevated BMI in persons of American Indian and Mexican ancestries. / Kasthuri, R. S.; McMillan, K. R.; Flood-Urdangarin, C.; Harvey, S. B.; Wilson-Grady, J. T.; Nelsestuen, G. L.

In: International Journal of Obesity, Vol. 31, No. 8, 01.08.2007, p. 1334-1336.

Research output: Contribution to journalArticle

Kasthuri, R. S. ; McMillan, K. R. ; Flood-Urdangarin, C. ; Harvey, S. B. ; Wilson-Grady, J. T. ; Nelsestuen, G. L. / Correlation of a T45S variant of apolipoprotein C1 with elevated BMI in persons of American Indian and Mexican ancestries. In: International Journal of Obesity. 2007 ; Vol. 31, No. 8. pp. 1334-1336.
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