Correlation between dynamic susceptibility contrast perfusion MRI and genomic alterations in glioblastoma

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


PURPOSE: To determine if dynamic susceptibility contrast perfusion MR imaging (DSC-pMRI) can predict significant genomic alterations in glioblastoma (GB).

METHODS: A total of 47 patients with treatment-naive GB (M/F: 23/24, mean age: 54 years, age range: 20-90 years) having DSC-pMRI with leakage correction and genomic analysis were reviewed. Mean relative cerebral blood volume (rCBV), maximum rCBV, relative percent signal recovery (rPSR), and relative peak height (rPH) were derived from T2* signal intensity-time curves by ROI analysis. Major genomic alterations of IDH1-132H, MGMT, p53, EGFR, ATRX, and PTEN status were correlated with DSC-pMRI-derived GB parameters. Statistical analysis was performed utilizing the independent-samples t-test, ROC (receiver operating characteristic) curve analysis, and multivariable stepwise regression model.

RESULTS: rCBVmean and rCBVmax were significantly different in relation to the IDH1, MGMT, p53, and PTEN mutation status (all p < 0.05). The rPH of the p53 mutation-positive GBs (mean 5.8 ± 2.8) was significantly higher than those of the p53 mutation-negative GBs (mean 4.0 ± 1.5) (p = 0.022). Multivariable stepwise regression analysis revealed that the presence of IDH-1 mutation (B = - 2.81, p = 0.005) was associated with decreased rCBVmean; PTEN mutation (B = - 1.21, p = 0.003) and MGMT methylation (B = - 1.47, p = 0.038) were associated with decreased rCBVmax; and ATRX loss (B = - 1.05, p = 0.008) was associated with decreased rPH.

CONCLUSION: Significant associations were identified between DSC-pMRI-derived parameters and major genomic alterations, including IDH-1 mutation, MGMT methylation, ATRX loss, and PTEN mutation status in GB.

Original languageEnglish (US)
Pages (from-to)1801-1810
Number of pages10
Issue number11
Early online dateMar 18 2021
StatePublished - Nov 2021

Bibliographical note

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Copyright 2021 Elsevier B.V., All rights reserved.


  • Alpha-thalassemia/mental retardation syndrome X-linked gene (ATRX)
  • Dynamic susceptibility contrast perfusion MR imaging (DSC-pMRI)
  • Glioblastoma (GB)
  • Isocitrate dehydrogenase-1 (IDH1)
  • O6-methylguanine-DNA methyltransferase (MGMT)

PubMed: MeSH publication types

  • Journal Article


Dive into the research topics of 'Correlation between dynamic susceptibility contrast perfusion MRI and genomic alterations in glioblastoma'. Together they form a unique fingerprint.

Cite this