Correlates of support for a nicotine-reduction policy in smokers with 6-week exposure to very low nicotine cigarettes

Rachel L. Denlinger-Apte, Jennifer W. Tidey, Joseph S. Koopmeiners, Dorothy K. Hatsukami, Tracy T. Smith, Lauren R. Pacek, F. Joseph Mcclernon, Eric C. Donny

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


BACKGROUND: The US Food and Drug Administration recently issued an advanced notice of proposed rule-making for reducing the nicotine content in cigarettes to a minimally addictive level. Very little is known about whether use of very low nicotine content (VLNC) cigarettes affects support for a nicotine reduction policy.

OBJECTIVE: This study examined the effects of using VLNC versus usual brand (UB) cigarettes on support for a nicotine reduction policy and determined whether participant characteristics and responses to VLNC cigarettes were associated with policy support.

METHODS: Participants from a cigarette trial who were assigned to either 0.4 mg nicotine/g tobacco research cigarettes or their UB for 6 weeks were asked about their support for the policy. χ 2 tests were used to compare support for the policy between cigarette conditions and logistic regression analyses were conducted to assess covariates associated with policy support.

FINDINGS: Policy support did not differ by condition. After 6 weeks of using VLNC cigarettes, 50% of participants supported the policy, 26% opposed and 24% responded 'Don't Know'. Support was higher among those adherent to smoking only VLNC cigarettes (65%) compared with those who were non-adherent (44%). Older participants and those interested in quitting had increased odds of support. Cigarette satisfaction, perceived harm and perceived nicotine content were not significantly associated with support.

CONCLUSIONS: Smoking VLNC cigarettes did not affect support for a nicotine reduction policy. Understanding predictors of policy support and opposition will help public health officials to maximise the public health acceptance and impact of this policy ( Identifier: NCT01681875 Post-Results).

Original languageEnglish (US)
Pages (from-to)352-355
Number of pages4
JournalTobacco control
Issue number3
StatePublished - May 1 2019

Bibliographical note

Publisher Copyright:
© Author(s) (or their employer(s)) 2019.


  • harm reduction
  • nicotine
  • public policy

PubMed: MeSH publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Journal Article
  • Research Support, N.I.H., Extramural


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