Coronary thrombolysis: Impact of clinical research on day-to-day practice

W. D. Rosamond, P. G. McGovern, R. V. Luepker

Research output: Contribution to journalArticlepeer-review


We evaluated the use of coronary thrombolytic therapy in community hospital practice during a time period when major clinical trials were shaping standards of care. Between 1990 and 1993, a prospective registry of patients with suspected acute myocardial infarction who were treated at six hospitals in a large metropolitan area was established. Of 1,225 enrolled patients with confirmed infarction, 37% of the men and 26% of the women received thrombolytic therapy. During the registry period, the use of tissue- type plasminogen activator declined while the use of streptokinase increased dramatically, coinciding with the release of results of a major clinical trial. This suggests that diffusion of information from clinical research to the community is rapid and has an impact on actual physician practice patterns.

Original languageEnglish (US)
Pages (from-to)12-16
Number of pages5
JournalCardiology Review
Issue number3
StatePublished - Dec 1 1997


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