Coronary heart disease, heart failure, and the risk of dementia: A systematic review and meta-analysis

Frank J. Wolters; Reffat A. Segufa; Sirwan K.L. Darweesh; Daniel Bos; Mohammad Arfan Ikram; Behnam Sabayan; Albert Hofman; Sanaz Sedaghat

doi:10.1016/j.jalz.2018.01.007

Coronary heart disease, heart failure, and the risk of dementia: A systematic review and meta-analysis

Frank J. Wolters
, Reffat A. Segufa
, Sirwan K.L. Darweesh
, Daniel Bos
, Mohammad Arfan Ikram
, Behnam Sabayan
, Albert Hofman
, Sanaz Sedaghat

Research output: Contribution to journal › Review article › peer-review

265 Scopus citations

Abstract

Introduction: Cardiovascular risk factors are closely linked with dementia risk, but whether heart disease predisposes to dementia is uncertain. Methods: We systematically reviewed the literature and meta-analyzed risk estimates from longitudinal studies reporting the association of coronary heart disease (CHD) or heart failure (HF) with risk of dementia. Results: We identified 16 studies (1,309,483 individuals) regarding CHD, and seven studies (1,958,702 individuals) about HF. A history of CHD was associated with a 27% increased risk of dementia (pooled relative risk [RR] [95% confidence interval, CI]: 1.27 [1.07–1.50]), albeit with considerable heterogeneity across studies (I² = 80%). HF was associated with 60% increased dementia risk (pooled RR 1.60 [1.19–2.13]) with moderate heterogeneity (I² = 59%). Among prospective population-based cohorts, pooled estimates were similar (for CHD, RR 1.26 [1.06–1.49], nine studies; and HF, RR 1.80 [1.41–2.31], four studies) and highly consistent (I² = 0%). Conclusion: CHD and HF are associated with an increased risk of dementia.

Original language	English (US)
Pages (from-to)	1493-1504
Number of pages	12
Journal	Alzheimer's and Dementia
Volume	14
Issue number	11
DOIs	https://doi.org/10.1016/j.jalz.2018.01.007
State	Published - Nov 2018
Externally published	Yes

Bibliographical note

Funding Information:
Sources of funding: This work was partially supported by an unrestricted grant from the Janssen Prevention Center. D.B. and F.J.W. received a fellowship from the Dutch Alzheimer Foundation (WE.15-2016-02).

Publisher Copyright:
© 2018 the Alzheimer's Association

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alzheimer's disease
Coronary heart disease
Dementia
Heart failure
Myocardial infarction

Publisher link

10.1016/j.jalz.2018.01.007

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title = "Coronary heart disease, heart failure, and the risk of dementia: A systematic review and meta-analysis",

abstract = "Introduction: Cardiovascular risk factors are closely linked with dementia risk, but whether heart disease predisposes to dementia is uncertain. Methods: We systematically reviewed the literature and meta-analyzed risk estimates from longitudinal studies reporting the association of coronary heart disease (CHD) or heart failure (HF) with risk of dementia. Results: We identified 16 studies (1,309,483 individuals) regarding CHD, and seven studies (1,958,702 individuals) about HF. A history of CHD was associated with a 27\% increased risk of dementia (pooled relative risk [RR] [95\% confidence interval, CI]: 1.27 [1.07{\textendash}1.50]), albeit with considerable heterogeneity across studies (I2 = 80\%). HF was associated with 60\% increased dementia risk (pooled RR 1.60 [1.19{\textendash}2.13]) with moderate heterogeneity (I2 = 59\%). Among prospective population-based cohorts, pooled estimates were similar (for CHD, RR 1.26 [1.06{\textendash}1.49], nine studies; and HF, RR 1.80 [1.41{\textendash}2.31], four studies) and highly consistent (I2 = 0\%). Conclusion: CHD and HF are associated with an increased risk of dementia.",

keywords = "Alzheimer's disease, Coronary heart disease, Dementia, Heart failure, Myocardial infarction",

author = "Wolters, \{Frank J.\} and Segufa, \{Reffat A.\} and Darweesh, \{Sirwan K.L.\} and Daniel Bos and Ikram, \{Mohammad Arfan\} and Behnam Sabayan and Albert Hofman and Sanaz Sedaghat",

note = "Funding Information: Sources of funding: This work was partially supported by an unrestricted grant from the Janssen Prevention Center. D.B. and F.J.W. received a fellowship from the Dutch Alzheimer Foundation (WE.15-2016-02). Publisher Copyright: {\textcopyright} 2018 the Alzheimer's Association",

year = "2018",

month = nov,

doi = "10.1016/j.jalz.2018.01.007",

language = "English (US)",

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journal = "Alzheimer's and Dementia",

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}

TY - JOUR

T1 - Coronary heart disease, heart failure, and the risk of dementia

T2 - A systematic review and meta-analysis

AU - Wolters, Frank J.

AU - Segufa, Reffat A.

AU - Darweesh, Sirwan K.L.

AU - Bos, Daniel

AU - Ikram, Mohammad Arfan

AU - Sabayan, Behnam

AU - Hofman, Albert

AU - Sedaghat, Sanaz

N1 - Funding Information: Sources of funding: This work was partially supported by an unrestricted grant from the Janssen Prevention Center. D.B. and F.J.W. received a fellowship from the Dutch Alzheimer Foundation (WE.15-2016-02). Publisher Copyright: © 2018 the Alzheimer's Association

PY - 2018/11

Y1 - 2018/11

N2 - Introduction: Cardiovascular risk factors are closely linked with dementia risk, but whether heart disease predisposes to dementia is uncertain. Methods: We systematically reviewed the literature and meta-analyzed risk estimates from longitudinal studies reporting the association of coronary heart disease (CHD) or heart failure (HF) with risk of dementia. Results: We identified 16 studies (1,309,483 individuals) regarding CHD, and seven studies (1,958,702 individuals) about HF. A history of CHD was associated with a 27% increased risk of dementia (pooled relative risk [RR] [95% confidence interval, CI]: 1.27 [1.07–1.50]), albeit with considerable heterogeneity across studies (I2 = 80%). HF was associated with 60% increased dementia risk (pooled RR 1.60 [1.19–2.13]) with moderate heterogeneity (I2 = 59%). Among prospective population-based cohorts, pooled estimates were similar (for CHD, RR 1.26 [1.06–1.49], nine studies; and HF, RR 1.80 [1.41–2.31], four studies) and highly consistent (I2 = 0%). Conclusion: CHD and HF are associated with an increased risk of dementia.

AB - Introduction: Cardiovascular risk factors are closely linked with dementia risk, but whether heart disease predisposes to dementia is uncertain. Methods: We systematically reviewed the literature and meta-analyzed risk estimates from longitudinal studies reporting the association of coronary heart disease (CHD) or heart failure (HF) with risk of dementia. Results: We identified 16 studies (1,309,483 individuals) regarding CHD, and seven studies (1,958,702 individuals) about HF. A history of CHD was associated with a 27% increased risk of dementia (pooled relative risk [RR] [95% confidence interval, CI]: 1.27 [1.07–1.50]), albeit with considerable heterogeneity across studies (I2 = 80%). HF was associated with 60% increased dementia risk (pooled RR 1.60 [1.19–2.13]) with moderate heterogeneity (I2 = 59%). Among prospective population-based cohorts, pooled estimates were similar (for CHD, RR 1.26 [1.06–1.49], nine studies; and HF, RR 1.80 [1.41–2.31], four studies) and highly consistent (I2 = 0%). Conclusion: CHD and HF are associated with an increased risk of dementia.

KW - Alzheimer's disease

KW - Coronary heart disease

KW - Dementia

KW - Heart failure

KW - Myocardial infarction

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Coronary heart disease, heart failure, and the risk of dementia: A systematic review and meta-analysis

Abstract

Bibliographical note

UN SDGs

Keywords

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