Coronary heart disease, heart failure, and the risk of dementia: A systematic review and meta-analysis

Frank J. Wolters, Reffat A. Segufa, Sirwan K.L. Darweesh, Daniel Bos, Mohammad Arfan Ikram, Behnam Sabayan, Albert Hofman, Sanaz Sedaghat

Research output: Contribution to journalReview articlepeer-review

143 Scopus citations


Introduction: Cardiovascular risk factors are closely linked with dementia risk, but whether heart disease predisposes to dementia is uncertain. Methods: We systematically reviewed the literature and meta-analyzed risk estimates from longitudinal studies reporting the association of coronary heart disease (CHD) or heart failure (HF) with risk of dementia. Results: We identified 16 studies (1,309,483 individuals) regarding CHD, and seven studies (1,958,702 individuals) about HF. A history of CHD was associated with a 27% increased risk of dementia (pooled relative risk [RR] [95% confidence interval, CI]: 1.27 [1.07–1.50]), albeit with considerable heterogeneity across studies (I2 = 80%). HF was associated with 60% increased dementia risk (pooled RR 1.60 [1.19–2.13]) with moderate heterogeneity (I2 = 59%). Among prospective population-based cohorts, pooled estimates were similar (for CHD, RR 1.26 [1.06–1.49], nine studies; and HF, RR 1.80 [1.41–2.31], four studies) and highly consistent (I2 = 0%). Conclusion: CHD and HF are associated with an increased risk of dementia.

Original languageEnglish (US)
Pages (from-to)1493-1504
Number of pages12
JournalAlzheimer's and Dementia
Issue number11
StatePublished - Nov 2018
Externally publishedYes

Bibliographical note

Funding Information:
Sources of funding: This work was partially supported by an unrestricted grant from the Janssen Prevention Center. D.B. and F.J.W. received a fellowship from the Dutch Alzheimer Foundation (WE.15-2016-02).

Publisher Copyright:
© 2018 the Alzheimer's Association


  • Alzheimer's disease
  • Coronary heart disease
  • Dementia
  • Heart failure
  • Myocardial infarction


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