Coronary and systemic hemodynamic effects of diazepam (Valium) in the unanesthetized dog

C. M. Bloor, A. S. Leon, D. E. Walker

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Homogenates of human brain tissue obtained at autopsy exhibit stereospecific binding of the potent narcotic analgesic 3H etorphine. Analysis of binding levels in 39 anatomic sites shows a wide range of regional variation but good consistency for the same area in different brains. Most sites with the highest binding activity lie within the limbic system. Evidence in the literature supporting the significance of the limbic system in responses to opiates is examined in the light of these findings.

Original languageEnglish (US)
Pages (from-to)1043-1051
Number of pages9
JournalRES.COMMUN.CHEM.PATH.PHARMACOL.
Volume6
Issue number3
StatePublished - Jan 1 1973

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