Coronary and systemic hemodynamic effects of diazepam (Valium) in the unanesthetized dog

C. M. Bloor; A. S. Leon; D. E. Walker

Coronary and systemic hemodynamic effects of diazepam (Valium) in the unanesthetized dog

C. M. Bloor, A. S. Leon, D. E. Walker

Kinesiology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Homogenates of human brain tissue obtained at autopsy exhibit stereospecific binding of the potent narcotic analgesic ³H etorphine. Analysis of binding levels in 39 anatomic sites shows a wide range of regional variation but good consistency for the same area in different brains. Most sites with the highest binding activity lie within the limbic system. Evidence in the literature supporting the significance of the limbic system in responses to opiates is examined in the light of these findings.

Original language	English (US)
Pages (from-to)	1043-1051
Number of pages	9
Journal	RES.COMMUN.CHEM.PATH.PHARMACOL.
Volume	6
Issue number	3
State	Published - 1973

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title = "Coronary and systemic hemodynamic effects of diazepam (Valium) in the unanesthetized dog",

abstract = "Homogenates of human brain tissue obtained at autopsy exhibit stereospecific binding of the potent narcotic analgesic 3H etorphine. Analysis of binding levels in 39 anatomic sites shows a wide range of regional variation but good consistency for the same area in different brains. Most sites with the highest binding activity lie within the limbic system. Evidence in the literature supporting the significance of the limbic system in responses to opiates is examined in the light of these findings.",

author = "Bloor, {C. M.} and Leon, {A. S.} and Walker, {D. E.}",

year = "1973",

language = "English (US)",

volume = "6",

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AU - Bloor, C. M.

AU - Leon, A. S.

AU - Walker, D. E.

PY - 1973

Y1 - 1973

N2 - Homogenates of human brain tissue obtained at autopsy exhibit stereospecific binding of the potent narcotic analgesic 3H etorphine. Analysis of binding levels in 39 anatomic sites shows a wide range of regional variation but good consistency for the same area in different brains. Most sites with the highest binding activity lie within the limbic system. Evidence in the literature supporting the significance of the limbic system in responses to opiates is examined in the light of these findings.

AB - Homogenates of human brain tissue obtained at autopsy exhibit stereospecific binding of the potent narcotic analgesic 3H etorphine. Analysis of binding levels in 39 anatomic sites shows a wide range of regional variation but good consistency for the same area in different brains. Most sites with the highest binding activity lie within the limbic system. Evidence in the literature supporting the significance of the limbic system in responses to opiates is examined in the light of these findings.

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ER -

Coronary and systemic hemodynamic effects of diazepam (Valium) in the unanesthetized dog

Abstract

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