Bretylium, 5 mg/kg administered to anesthetized dogs resulted in a sharp increase in coronary blood flow with a parallel increase in systemic arterial pressure. After depletion of endogenous catecholamines with reserpine, bretylium administration produced a significant increase in coronary vascular resistance and no increase in coronary blood flow.
|Original language||English (US)|
|Number of pages||8|
|State||Published - Dec 1 1973|