Coronary and systemic haemodynamic effects of bretylium in the intact unanaesthetized dog

Robert J Bache, F. R. Cobb, J. C. Greenfield

Research output: Contribution to journalArticle

Abstract

Bretylium, 5 mg/kg administered to anesthetized dogs resulted in a sharp increase in coronary blood flow with a parallel increase in systemic arterial pressure. After depletion of endogenous catecholamines with reserpine, bretylium administration produced a significant increase in coronary vascular resistance and no increase in coronary blood flow.

Original languageEnglish (US)
Pages (from-to)755-762
Number of pages8
JournalCardiovascular Research
Volume7
Issue number6
StatePublished - Dec 1 1973

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Hemodynamics
Dogs
Reserpine
Vascular Resistance
Catecholamines
Arterial Pressure
bretylium

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Coronary and systemic haemodynamic effects of bretylium in the intact unanaesthetized dog. / Bache, Robert J; Cobb, F. R.; Greenfield, J. C.

In: Cardiovascular Research, Vol. 7, No. 6, 01.12.1973, p. 755-762.

Research output: Contribution to journalArticle

Bache, RJ, Cobb, FR & Greenfield, JC 1973, 'Coronary and systemic haemodynamic effects of bretylium in the intact unanaesthetized dog', Cardiovascular Research, vol. 7, no. 6, pp. 755-762.
Bache, Robert J ; Cobb, F. R. ; Greenfield, J. C. / Coronary and systemic haemodynamic effects of bretylium in the intact unanaesthetized dog. In: Cardiovascular Research. 1973 ; Vol. 7, No. 6. pp. 755-762.
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