Cord transferrin and ferritin values in newborn infants at risk for prenatal uteroplacental insufficiency and chronic hypoxia

Uma M. Chockalingam, Edrie Murphy, Janice C. Ophoven, Sally A. Weisdorf, Michael K Georgieff

Research output: Contribution to journalArticlepeer-review

104 Scopus citations

Abstract

We measured cord transferrin and ferritin levels in 50 newborn infants with fetal conditions associated with either uteroplacental vascular insufficiency or chronic hypoxia. Sixteen small for gestational age infants, 21 infants of mothers with preeclampsia, and 13 symptomatic infants of diabetic mothers had significantly higher transferrin levels and lower ferritin levels and calculated iron stores than did asymptomatic gestational age-matched control infants without these conditions. Cord ferritin levels and calculated iron stores were significantly lower in the infants of diabetic mothers than in any other group of infants. Cord transferrin levels were inversely correlated with ferritin levels (r=-0.59, P<0.001) and were unrelated to transthyretin levels and birth weight in the high-risk infants, but were positively correlated with ferritin levels (r=0.50, P<0.001), transthyretin levels (r=0.65, P<0.001), and birth weight (r=0.75, P<0.001) in the control infants. We conclude that cord transferrin levels do not reflect protein-energy status in newborn infants with prenatal histories suggesting uteroplacental insufficiency or chronic hypoxia, and that when associated with decreased cord ferritin levels, indicate possible impaired iron stores in these infants.

Original languageEnglish (US)
Pages (from-to)283-286
Number of pages4
JournalThe Journal of pediatrics
Volume111
Issue number2
DOIs
StatePublished - Aug 1987

Fingerprint Dive into the research topics of 'Cord transferrin and ferritin values in newborn infants at risk for prenatal uteroplacental insufficiency and chronic hypoxia'. Together they form a unique fingerprint.

Cite this