Abstract
A copper-mediated bromoamination of aromatic N-heterocycles has been achieved using oxime esters as the N-reagents under mild conditions (ca. 70 °C). The reaction with N-alkyl indoles proceeds regioselectively to produce the 2-amino-3-bromo indole derivatives as confirmed by X-ray crystallographic analysis of the bromoaminated product, 3aa-Br. With N-methylpyrrole both the monobromoaminated and dibromoaminated products were produced by this method.
Original language | English (US) |
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Pages (from-to) | 7914-7920 |
Number of pages | 7 |
Journal | Organometallics |
Volume | 31 |
Issue number | 22 |
DOIs | |
State | Published - Nov 26 2012 |