Copper-catalyzed [18F]fluorination of (Mesityl)(aryl)iodonium salts

Naoko Ichiishi, Allen F. Brooks, Joseph J. Topczewski, Melissa E. Rodnick, Melanie S. Sanford, Peter J.H. Scott

Research output: Contribution to journalArticlepeer-review

133 Scopus citations

Abstract

A practical, rapid, and highly regioselective Cu-catalyzed radiofluorination of (mesityl)(aryl)iodonium salts is described. This protocol utilizes [18F]KF to access 18F-labeled electron-rich, -neutral, and -deficient aryl fluorides under a single set of mild conditions. This methodology is applied to the synthesis of protected versions of two important radiotracers: 4-[18F]fluorophenylalanine and 6-[ 18F]fluoroDOPA.

Original languageEnglish (US)
Pages (from-to)3224-3227
Number of pages4
JournalOrganic Letters
Volume16
Issue number12
DOIs
StatePublished - Jun 20 2014

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