Copper-catalyzed oxidative decarboxylative C-H arylation of benzoxazoles with 2-nitrobenzoic acids

Lijun Chen; Lin Ju; Katelyn A. Bustin; Jessica M. Hoover

doi:10.1039/c5cc06645j

Copper-catalyzed oxidative decarboxylative C-H arylation of benzoxazoles with 2-nitrobenzoic acids

Lijun Chen, Lin Ju, Katelyn A. Bustin, Jessica M. Hoover

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64 Scopus citations

Abstract

A copper-catalyzed oxidative decarboxylative coupling of benzoxazoles with 2-nitrobenzoic acids was developed. This methodology favors electron-rich benzoxazoles and electron-deficient benzoic acids and enables the preparation of a variety of arylated benzoxazoles in good yields. The trends in product yields suggest a delicate balance between the decarboxylation and C-H arylation steps.

Original language	English (US)
Pages (from-to)	15059-15062
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	81
DOIs	https://doi.org/10.1039/c5cc06645j
State	Published - Aug 21 2015
Externally published	Yes

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© 2015 The Royal Society of Chemistry.

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10.1039/c5cc06645j

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abstract = "A copper-catalyzed oxidative decarboxylative coupling of benzoxazoles with 2-nitrobenzoic acids was developed. This methodology favors electron-rich benzoxazoles and electron-deficient benzoic acids and enables the preparation of a variety of arylated benzoxazoles in good yields. The trends in product yields suggest a delicate balance between the decarboxylation and C-H arylation steps.",

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AU - Hoover, Jessica M.

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AB - A copper-catalyzed oxidative decarboxylative coupling of benzoxazoles with 2-nitrobenzoic acids was developed. This methodology favors electron-rich benzoxazoles and electron-deficient benzoic acids and enables the preparation of a variety of arylated benzoxazoles in good yields. The trends in product yields suggest a delicate balance between the decarboxylation and C-H arylation steps.

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Copper-catalyzed oxidative decarboxylative C-H arylation of benzoxazoles with 2-nitrobenzoic acids

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