Copper-catalyzed amidation of 2-phenylpyridine with oxygen as the terminal oxidant

Alex John, Kenneth M. Nicholas

Research output: Contribution to journalArticlepeer-review

156 Scopus citations

Abstract

The Cu(OAc)2-catalyzed, O2-mediated amidation of 2-phenylpyridine via C-H bond activation is reported. A variety of nitrogen reagents including sulfonamides, carboxamides, and anilines participate in the reaction in moderate to good yields.

Original languageEnglish (US)
Pages (from-to)4158-4162
Number of pages5
JournalJournal of Organic Chemistry
Volume76
Issue number10
DOIs
StatePublished - May 20 2011

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