Copper-assisted palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids

Yong Wook Kim, Micah J. Niphakis, Gunda I. Georg

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Described herein is a palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids. The versatility of this method is that both electron-rich and electron-poor boronic acids can be coupled in high yields. A mixture of two Cu(II) additives was crucial for efficient cross-coupling. The role of each Cu(II) reagent appears to be distinct and complementary serving to assist catalyst reoxidation and transmetalation through a putative arylcopper intermediate.

Original languageEnglish (US)
Pages (from-to)9496-9503
Number of pages8
JournalJournal of Organic Chemistry
Volume77
Issue number21
DOIs
StatePublished - Nov 2 2012

Fingerprint Dive into the research topics of 'Copper-assisted palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids'. Together they form a unique fingerprint.

Cite this