Coordination microparticle vaccines engineered from tumor cell templates

Xiaoli Wang; Jiayi Liang; Chuangnian Zhang; Guilei Ma; Chun Wang; Deling Kong

doi:10.1039/c8cc10004g

Coordination microparticle vaccines engineered from tumor cell templates

Xiaoli Wang, Jiayi Liang, Chuangnian Zhang, Guilei Ma, Chun Wang, Deling Kong

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Abstract

A method for encapsulation of individual tumor cells with an epigallocatechin-3-gallate (EGCG)-Al(iii) coordination layer, which can be used as potential tumor vaccines, was developed. The interaction between microparticle vaccines and dendritic cells was investigated in vitro. The microparticles (∼10 μm) were efficiently internalized by DCs with enhanced uptake efficiency via actin polymerization and clathrin-mediated endocytosis.

Original language	English (US)
Pages (from-to)	1568-1571
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	11
DOIs	https://doi.org/10.1039/c8cc10004g
State	Published - 2019

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Publisher Copyright:
© 2019 The Royal Society of Chemistry.

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10.1039/c8cc10004g

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abstract = "A method for encapsulation of individual tumor cells with an epigallocatechin-3-gallate (EGCG)-Al(iii) coordination layer, which can be used as potential tumor vaccines, was developed. The interaction between microparticle vaccines and dendritic cells was investigated in vitro. The microparticles (∼10 μm) were efficiently internalized by DCs with enhanced uptake efficiency via actin polymerization and clathrin-mediated endocytosis.",

author = "Xiaoli Wang and Jiayi Liang and Chuangnian Zhang and Guilei Ma and Chun Wang and Deling Kong",

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T1 - Coordination microparticle vaccines engineered from tumor cell templates

AU - Wang, Xiaoli

AU - Liang, Jiayi

AU - Zhang, Chuangnian

AU - Ma, Guilei

AU - Wang, Chun

AU - Kong, Deling

PY - 2019

Y1 - 2019

N2 - A method for encapsulation of individual tumor cells with an epigallocatechin-3-gallate (EGCG)-Al(iii) coordination layer, which can be used as potential tumor vaccines, was developed. The interaction between microparticle vaccines and dendritic cells was investigated in vitro. The microparticles (∼10 μm) were efficiently internalized by DCs with enhanced uptake efficiency via actin polymerization and clathrin-mediated endocytosis.

AB - A method for encapsulation of individual tumor cells with an epigallocatechin-3-gallate (EGCG)-Al(iii) coordination layer, which can be used as potential tumor vaccines, was developed. The interaction between microparticle vaccines and dendritic cells was investigated in vitro. The microparticles (∼10 μm) were efficiently internalized by DCs with enhanced uptake efficiency via actin polymerization and clathrin-mediated endocytosis.

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DO - 10.1039/c8cc10004g

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JO - Chemical Communications

JF - Chemical Communications

IS - 11

ER -

Coordination microparticle vaccines engineered from tumor cell templates

Abstract

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