Coordination microparticle vaccines engineered from tumor cell templates

Xiaoli Wang; Jiayi Liang; Chuangnian Zhang; Guilei Ma; Chun Wang; Deling Kong

doi:10.1039/c8cc10004g

Coordination microparticle vaccines engineered from tumor cell templates

Xiaoli Wang, Jiayi Liang, Chuangnian Zhang, Guilei Ma, Chun Wang, Deling Kong

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A method for encapsulation of individual tumor cells with an epigallocatechin-3-gallate (EGCG)-Al(iii) coordination layer, which can be used as potential tumor vaccines, was developed. The interaction between microparticle vaccines and dendritic cells was investigated in vitro. The microparticles (∼10 μm) were efficiently internalized by DCs with enhanced uptake efficiency via actin polymerization and clathrin-mediated endocytosis.

Original language	English (US)
Pages (from-to)	1568-1571
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	11
DOIs	https://doi.org/10.1039/c8cc10004g
State	Published - 2019

Bibliographical note

Funding Information:
This work was supported by the National Natural Science Foundation of China (31600743, 81673027), the Natural Science Foundation of Tianjin City (16JCQNJC13900, 18JCQNJC14500), the CAMS Innovation Fund for Medical Sciences (CAMS-I2M-3-026), and the Tianjin Natural Science Fund for Distinguished Young Scholars (17JCJQJC46400).

Publisher Copyright:
© 2019 The Royal Society of Chemistry.

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abstract = "A method for encapsulation of individual tumor cells with an epigallocatechin-3-gallate (EGCG)-Al(iii) coordination layer, which can be used as potential tumor vaccines, was developed. The interaction between microparticle vaccines and dendritic cells was investigated in vitro. The microparticles (∼10 μm) were efficiently internalized by DCs with enhanced uptake efficiency via actin polymerization and clathrin-mediated endocytosis.",

author = "Xiaoli Wang and Jiayi Liang and Chuangnian Zhang and Guilei Ma and Chun Wang and Deling Kong",

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TY - JOUR

T1 - Coordination microparticle vaccines engineered from tumor cell templates

AU - Wang, Xiaoli

AU - Liang, Jiayi

AU - Zhang, Chuangnian

AU - Ma, Guilei

AU - Wang, Chun

AU - Kong, Deling

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (31600743, 81673027), the Natural Science Foundation of Tianjin City (16JCQNJC13900, 18JCQNJC14500), the CAMS Innovation Fund for Medical Sciences (CAMS-I2M-3-026), and the Tianjin Natural Science Fund for Distinguished Young Scholars (17JCJQJC46400). Publisher Copyright: © 2019 The Royal Society of Chemistry.

PY - 2019

Y1 - 2019

N2 - A method for encapsulation of individual tumor cells with an epigallocatechin-3-gallate (EGCG)-Al(iii) coordination layer, which can be used as potential tumor vaccines, was developed. The interaction between microparticle vaccines and dendritic cells was investigated in vitro. The microparticles (∼10 μm) were efficiently internalized by DCs with enhanced uptake efficiency via actin polymerization and clathrin-mediated endocytosis.

AB - A method for encapsulation of individual tumor cells with an epigallocatechin-3-gallate (EGCG)-Al(iii) coordination layer, which can be used as potential tumor vaccines, was developed. The interaction between microparticle vaccines and dendritic cells was investigated in vitro. The microparticles (∼10 μm) were efficiently internalized by DCs with enhanced uptake efficiency via actin polymerization and clathrin-mediated endocytosis.

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ER -

Coordination microparticle vaccines engineered from tumor cell templates

Abstract

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