Cooperative omega loops in cytochrome c: Role in folding and function

Mallela M.G. Krishna; Yan Lin; Jon N. Rumbley; S. Walter Englander

doi:10.1016/S0022-2836(03)00697-1

Cooperative omega loops in cytochrome c: Role in folding and function

Mallela M.G. Krishna, Yan Lin, Jon N. Rumbley, S. Walter Englander

Pharmacy Practice and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

148 Scopus citations

Abstract

Hydrogen exchange experiments under slow exchange conditions show that an omega loop in cytochrome c (residues 40-57) acts as a cooperative unfolding/refolding unit under native conditions. This unit behavior accounts for an initial step on the unfolding pathway, a final step in refolding, and a number of other structural, functional and evolutionary properties.

Original language	English (US)
Pages (from-to)	29-36
Number of pages	8
Journal	Journal of Molecular Biology
Volume	331
Issue number	1
DOIs	https://doi.org/10.1016/S0022-2836(03)00697-1
State	Published - Aug 1 2003

Bibliographical note

Funding Information:
This work was supported by research grants from the NIH and the Mathers Foundation.

Keywords

Cytochrome c
Hydrogen exchange
Omega loop
Protein folding
Protein function

Publisher link

10.1016/S0022-2836(03)00697-1

Find It

Find It at U of M Libraries

Cite this

@article{d8f267e46b5f4b7594e6018ee9c7187b,

title = "Cooperative omega loops in cytochrome c: Role in folding and function",

abstract = "Hydrogen exchange experiments under slow exchange conditions show that an omega loop in cytochrome c (residues 40-57) acts as a cooperative unfolding/refolding unit under native conditions. This unit behavior accounts for an initial step on the unfolding pathway, a final step in refolding, and a number of other structural, functional and evolutionary properties.",

keywords = "Cytochrome c, Hydrogen exchange, Omega loop, Protein folding, Protein function",

author = "Krishna, \{Mallela M.G.\} and Yan Lin and Rumbley, \{Jon N.\} and Englander, \{S. Walter\}",

note = "Funding Information: This work was supported by research grants from the NIH and the Mathers Foundation.",

year = "2003",

month = aug,

day = "1",

doi = "10.1016/S0022-2836(03)00697-1",

language = "English (US)",

volume = "331",

pages = "29--36",

journal = "Journal of Molecular Biology",

issn = "0022-2836",

publisher = "Academic Press",

number = "1",

}

TY - JOUR

T1 - Cooperative omega loops in cytochrome c

T2 - Role in folding and function

AU - Krishna, Mallela M.G.

AU - Lin, Yan

AU - Rumbley, Jon N.

AU - Englander, S. Walter

N1 - Funding Information: This work was supported by research grants from the NIH and the Mathers Foundation.

PY - 2003/8/1

Y1 - 2003/8/1

N2 - Hydrogen exchange experiments under slow exchange conditions show that an omega loop in cytochrome c (residues 40-57) acts as a cooperative unfolding/refolding unit under native conditions. This unit behavior accounts for an initial step on the unfolding pathway, a final step in refolding, and a number of other structural, functional and evolutionary properties.

AB - Hydrogen exchange experiments under slow exchange conditions show that an omega loop in cytochrome c (residues 40-57) acts as a cooperative unfolding/refolding unit under native conditions. This unit behavior accounts for an initial step on the unfolding pathway, a final step in refolding, and a number of other structural, functional and evolutionary properties.

KW - Cytochrome c

KW - Hydrogen exchange

KW - Omega loop

KW - Protein folding

KW - Protein function

UR - https://www.scopus.com/pages/publications/0038786579

UR - https://www.scopus.com/inward/citedby.url?scp=0038786579&partnerID=8YFLogxK

U2 - 10.1016/S0022-2836(03)00697-1

DO - 10.1016/S0022-2836(03)00697-1

M3 - Article

C2 - 12875833

AN - SCOPUS:0038786579

SN - 0022-2836

VL - 331

SP - 29

EP - 36

JO - Journal of Molecular Biology

JF - Journal of Molecular Biology

IS - 1

ER -

Cooperative omega loops in cytochrome c: Role in folding and function

Abstract

Bibliographical note

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this