Cooperative omega loops in cytochrome c: Role in folding and function

Mallela M.G. Krishna; Yan Lin; Jon N. Rumbley; S. Walter Englander

doi:10.1016/S0022-2836(03)00697-1

Cooperative omega loops in cytochrome c: Role in folding and function

Mallela M.G. Krishna, Yan Lin, Jon N. Rumbley, S. Walter Englander

Pharmacy Practice and Pharmaceutical Sciences

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133 Scopus citations

Abstract

Hydrogen exchange experiments under slow exchange conditions show that an omega loop in cytochrome c (residues 40-57) acts as a cooperative unfolding/refolding unit under native conditions. This unit behavior accounts for an initial step on the unfolding pathway, a final step in refolding, and a number of other structural, functional and evolutionary properties.

Original language	English (US)
Pages (from-to)	29-36
Number of pages	8
Journal	Journal of Molecular Biology
Volume	331
Issue number	1
DOIs	https://doi.org/10.1016/S0022-2836(03)00697-1
State	Published - Aug 1 2003

Bibliographical note

Funding Information:
This work was supported by research grants from the NIH and the Mathers Foundation.

Keywords

Cytochrome c
Hydrogen exchange
Omega loop
Protein folding
Protein function

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10.1016/S0022-2836(03)00697-1

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keywords = "Cytochrome c, Hydrogen exchange, Omega loop, Protein folding, Protein function",

author = "Krishna, {Mallela M.G.} and Yan Lin and Rumbley, {Jon N.} and Englander, {S. Walter}",

note = "Funding Information: This work was supported by research grants from the NIH and the Mathers Foundation.",

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AU - Lin, Yan

AU - Rumbley, Jon N.

AU - Englander, S. Walter

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AB - Hydrogen exchange experiments under slow exchange conditions show that an omega loop in cytochrome c (residues 40-57) acts as a cooperative unfolding/refolding unit under native conditions. This unit behavior accounts for an initial step on the unfolding pathway, a final step in refolding, and a number of other structural, functional and evolutionary properties.

KW - Cytochrome c

KW - Hydrogen exchange

KW - Omega loop

KW - Protein folding

KW - Protein function

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ER -

Cooperative omega loops in cytochrome c: Role in folding and function

Abstract

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Keywords

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