Cooperative omega loops in cytochrome c: Role in folding and function

Mallela M.G. Krishna, Yan Lin, Jon N. Rumbley, S. Walter Englander

Research output: Contribution to journalArticlepeer-review

141 Scopus citations


Hydrogen exchange experiments under slow exchange conditions show that an omega loop in cytochrome c (residues 40-57) acts as a cooperative unfolding/refolding unit under native conditions. This unit behavior accounts for an initial step on the unfolding pathway, a final step in refolding, and a number of other structural, functional and evolutionary properties.

Original languageEnglish (US)
Pages (from-to)29-36
Number of pages8
JournalJournal of Molecular Biology
Issue number1
StatePublished - Aug 1 2003

Bibliographical note

Funding Information:
This work was supported by research grants from the NIH and the Mathers Foundation.


  • Cytochrome c
  • Hydrogen exchange
  • Omega loop
  • Protein folding
  • Protein function


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