Cooperative catalysis approach to intramolecular hydroacylation

Evgeny V. Beletskiy; Sudheer Chava; Christopher J Douglas

doi:10.1021/jo300779q

Cooperative catalysis approach to intramolecular hydroacylation

Evgeny V. Beletskiy, Sudheer Chava, Christopher J Douglas

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Prior examples of hydroacylation to form six- and seven-membered ring ketones require either embedded chelating groups or other substrate design strategies to circumvent competitive aldehyde decarbonylation. A cooperative catalysis strategy enabled intramolecular hydroacylation of disubstituted alkenes to form seven- and six-membered rings without requiring substrate-embedded chelating groups.

Original language	English (US)
Pages (from-to)	5884-5893
Number of pages	10
Journal	Journal of Organic Chemistry
Volume	77
Issue number	14
DOIs	https://doi.org/10.1021/jo300779q
State	Published - Jul 20 2012

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title = "Cooperative catalysis approach to intramolecular hydroacylation",

abstract = "Prior examples of hydroacylation to form six- and seven-membered ring ketones require either embedded chelating groups or other substrate design strategies to circumvent competitive aldehyde decarbonylation. A cooperative catalysis strategy enabled intramolecular hydroacylation of disubstituted alkenes to form seven- and six-membered rings without requiring substrate-embedded chelating groups.",

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AU - Chava, Sudheer

AU - Douglas, Christopher J

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N2 - Prior examples of hydroacylation to form six- and seven-membered ring ketones require either embedded chelating groups or other substrate design strategies to circumvent competitive aldehyde decarbonylation. A cooperative catalysis strategy enabled intramolecular hydroacylation of disubstituted alkenes to form seven- and six-membered rings without requiring substrate-embedded chelating groups.

AB - Prior examples of hydroacylation to form six- and seven-membered ring ketones require either embedded chelating groups or other substrate design strategies to circumvent competitive aldehyde decarbonylation. A cooperative catalysis strategy enabled intramolecular hydroacylation of disubstituted alkenes to form seven- and six-membered rings without requiring substrate-embedded chelating groups.

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Cooperative catalysis approach to intramolecular hydroacylation

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