Following administration of d-α-tocopherol-5-methyl-C14 to rats, a labeled metabolite has been isolated from the liver which has been identified by chromatographic and carrier crystallization methods as tocopheryl quinone. Evidence also has been found for the natural occurrence of trace quantities of this compound in liver and muscle extracts of mice and pigs. The presence of a second major metabolite in the tissues of these animals has been demonstrated.
Bibliographical noteFunding Information:
1 This work was supported by research grants from the Xational S;cienre Foundation (G-8681) and the Muscular Dystrophy Associations of Amcr-ica, Inca. ” Present addres,s : Institute of Metabolic s~ar(~h, Highland Hospital, Oakland 6, Calif.