Conversion of a polysaccharide to nitric oxide-releasing form. Dual-mechanism anticoagulant activity of diazeniumdiolated heparin

Joseph E. Saavedra, Daniel L. Mooradian, Kelly A. Mowery, Mark H. Schoenfisch, Michael L. Citro, Keith M. Davies, Mark E. Meyerhoff, Larry K. Keefer

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

We describe heparin/diazeniumdiolate conjugates that generate nitric oxide (NO) at physiological pH. Like the heparin from which they were prepared, they inhibit thrombin-induced blood coagulation. Unlike heparin, they can also inhibit and reverse ADP-induced platelet aggregation (as expected for an NO-releasing agent), suggesting potential utility as dual-action antithrombotics. Published by Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)751-753
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number8
DOIs
StatePublished - Apr 2000

Bibliographical note

Funding Information:
The technical assistance of Steven Burris is greatly appreciated. This project was funded in part through NIH grant GM-56991 and by the National Cancer Institute under contract NO1-CO-56000.

Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.

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