Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure

Joel L. Berry, Wuqiang Zhu, Yao Liang Tang, Prasanna Krishnamurthy, Ying Ge, John P. Cooke, Yabing Chen, Daniel J. Garry, Huang Tian Yang, Namakkal Soorapan Rajasekaran, Walter J. Koch, Song Li, Keitaro Domae, Gangjian Qin, Ke Cheng, Timothy J. Kamp, Lei Ye, Shijun Hu, Brenda M. Ogle, Jack M. RogersE. Dale Abel, Michael E. Davis, Sumanth D. Prabhu, Ronglih Liao, William T. Pu, Yibin Wang, Peipei Ping, Nenad Bursac, Gordana Vunjak-Novakovic, Joseph C. Wu, Roberto Bolli, Philippe Menasché, Jianyi Zhang

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

On March 1 and 2, 2018, the National Institutes of Health 2018 Progenitor Cell Translational Consortium, Cardiovascular Bioengineering Symposium, was held at the University of Alabama at Birmingham. Convergence of life sciences and engineering to advance the understanding and treatment of heart failure was the theme of the meeting. Over 150 attendees were present, and >40 scientists presented their latest work on engineering human functional myocardium for disease modeling, drug development, and heart failure research. The scientists, engineers, and physicians in the field of cardiovascular sciences met and discussed the most recent advances in their work and proposed future strategies for overcoming the major roadblocks of cardiovascular bioengineering and therapy. Particular emphasis was given for manipulation and using of stem/progenitor cells, biomaterials, and methods to provide molecular, chemical, and mechanical cues to cells to influence their identity and fate in vitro and in vivo. Collectively, these works are profoundly impacting and progressing toward deciphering the mechanisms and developing novel treatments for left ventricular dysfunction of failing hearts. Here, we present some important perspectives that emerged from this meeting.

Original languageEnglish (US)
Pages (from-to)161-169
Number of pages9
JournalCirculation research
Volume124
Issue number1
DOIs
StatePublished - Jan 4 2019

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Keywords

  • bioengineering
  • heart failure
  • myocardium
  • stem cells
  • tissue engineering

PubMed: MeSH publication types

  • Congress
  • Research Support, N.I.H., Extramural

Cite this

Berry, J. L., Zhu, W., Tang, Y. L., Krishnamurthy, P., Ge, Y., Cooke, J. P., Chen, Y., Garry, D. J., Yang, H. T., Rajasekaran, N. S., Koch, W. J., Li, S., Domae, K., Qin, G., Cheng, K., Kamp, T. J., Ye, L., Hu, S., Ogle, B. M., ... Zhang, J. (2019). Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circulation research, 124(1), 161-169. https://doi.org/10.1161/CIRCRESAHA.118.314216