Controversies in epilepsy: Debates held during the Fourth International Workshop on Seizure Prediction

Mark G. Frei, Hitten P. Zaveri, Susan Arthurs, Gregory K. Bergey, Christophe C. Jouny, Klaus Lehnertz, Jean Gotman, Ivan Osorio, Theoden I. Netoff, Walter J. Freeman, John Jefferys, Gregory Worrell, Michel Le Van Quyen, Steven J. Schiff, Florian Mormann

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


Debates on six controversial topics were held during the Fourth International Workshop on Seizure Prediction (IWSP4) convened in Kansas City, KS, USA, July 4-7, 2009. The topics were (1) Ictogenesis: Focus versus Network? (2) Spikes and Seizures: Step-relatives or Siblings? (3) Ictogenesis: A Result of Hyposynchrony? (4) Can Focal Seizures Be Caused by Excessive Inhibition? (5) Do High-Frequency Oscillations Provide Relevant Independent Information? (6) Phase Synchronization: Is It Worthwhile as Measured? This article, written by the IWSP4 organizing committee and the debaters, summarizes the arguments presented during the debates.

Original languageEnglish (US)
Pages (from-to)4-16
Number of pages13
JournalEpilepsy and Behavior
Issue number1
StatePublished - Sep 2010

Bibliographical note

Funding Information:
Funding for IWSP4 was received from the following foundations, government agencies, industries, university and hospital partners, and individuals: Alliance for Epilepsy Research, UCB, Cyberonics, Deutsche Gesellschaft für Epileptologie, NeuroVista, American Epilepsy Society, CURE, University of Kansas Medical Center, Children's Mercy Hospitals and Clinics, Honeywell—Kansas City Plant, Ad-Tech, Cardinal Health, Medtronic, DIXI, Boulevard Brewing Company, and Mary Shaw Branton, Don Alexander, and Frank and Helen Wewers. Funding was also made possible in part by Grant R13NS065535 from the National Institute of Neurological Disorders and Stroke (NINDS), Office of Rare Disease Research (ORDR), and National Institute of Child Health and Human Development (NICHD). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily represent the official views of the NINDS, ORDR, NICHD, or National Institutes of Health (NIH) and do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Funding Information:
This work was supported by funding from the Epilepsy Therapy and Development Program (G.W.), National Institutes of Health R01-NS 06939 (G.W.), and the European Union-FP7 Project EPILEPSIAE (Evolving Platform for Improving Living Expectation of Patients Suffering from IctAl Events, Grant 211713 [M.L.V.Q.]).


  • Excitation
  • High-frequency activity
  • High-frequency oscillations
  • Hypersynchrony
  • Hyposynchrony
  • Ictogenesis
  • Inhibition
  • Interictal activity
  • Network
  • Phase synchronization
  • Seizure focus
  • Seizure onset area
  • Spikes


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