Controlling the structure of proteins at surfaces

Michael Geisler, Senbo Xiao, Elias M. Puchner, Frauke Gräter, Thorsten Hugel

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


With the help of single molecule force spectroscopy and molecular dynamics simulations, we determine the surface-induced structure of a single engineered spider silk protein. An amyloid like structure is induced in the vicinity of a surface with high surface energy and can be prohibited in the presence of a hydrophobic surface. The derived molecular energy landscapes highlight the role of single silk protein structure for the macroscopic toughness of spider silk.

Original languageEnglish (US)
Pages (from-to)17277-17281
Number of pages5
JournalJournal of the American Chemical Society
Issue number48
StatePublished - Dec 8 2010


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