Controlling spike timing and synchrony in oscillatory neurons

Tyler Stigen, Per Danzl, Jeff Moehlis, Theoden Netoff

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


We describe an algorithm to control synchrony between two periodically firing neurons. The control scheme operates in real-time using a dynamic clamp platform. This algorithm is a low-impact stimulation method that brings the neurons toward the desired level of synchrony over the course of several neuron firing periods. As a proof of principle, we demonstrate the versatility of the algorithm using real-time conductance models and then show its performance with biological neurons of hippocampal region CA1 and entorhinal cortex.

Original languageEnglish (US)
Pages (from-to)2074-2082
Number of pages9
JournalJournal of neurophysiology
Issue number5
StatePublished - May 2011


  • Deep brain stimulation
  • Dynamic clamp
  • Phaseresponse curve
  • Spike time controller
  • Synchrony controller


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